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Changes in programmed death-ligand 1 expression during cisplatin treatment in patients with head and neck squamous cell carcinoma
DC Field | Value | Language |
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dc.contributor.author | Ock, Chan-Young | - |
dc.contributor.author | Kim, Sehui | - |
dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Kim, Soyeon | - |
dc.contributor.author | Ahn, Yong-Oon | - |
dc.contributor.author | Chung, Eun-Jae | - |
dc.contributor.author | Kim, Jin-Ho | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Kwon, Seong Keun | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.contributor.author | Jung, Kyeong Chun | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Wu, Hong-Gyun | - |
dc.contributor.author | Sung, Myung Whun | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.date.accessioned | 2020-04-27T11:07:10Z | - |
dc.date.available | 2020-04-27T11:07:10Z | - |
dc.date.created | 2018-07-19 | - |
dc.date.created | 2018-07-19 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.citation | Oncotarget, Vol.8 No.58, pp.97920-97927 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.other | 40618 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165252 | - |
dc.description.abstract | Programmed death-ligand 1 (PD-L1) expression is regarded as a predictive marker for anti-PD-1/PD-L1 therapy. The purpose of study was to explore the changes in PD-L1 expression in head and neck squamous cell carcinoma (HNSCC) during treatment. Paired HNSCC tissues prior to and after cisplatin-based treatment were evaluated to determine PD-L1 protein expression by immunohistochemistry. Among the 35 HNSCC patient samples, PD-L1 expression status changed after treatment in 37.1% (13/35) of samples. Among the 13 patients whose baseline PD-L1 was negative, PD-L1 expression was increased in 9 cases (69.2%) and remained negative in 4 cases (30.8%, P = 0.003). Patients exposed to cisplatin generally showed PDL1 up-regulation (83.3%, P = 0.037) compared to those not exposed to cisplatin (57.1%, P = 0.072). To validate these findings in vitro, changes in PD-L1 expression in HNSCC cell lines (Detroit-562, PCI-13, SNU-1041, SNU-1066, SNU-1076, and FaDu) were analyzed by western blotting and flow cytometry after treatment with cisplatin and interferon-gamma. In HNSCC cell lines, PD-L1 expression was significantly upregulated after cisplatin, along with phosphor-MAPK/ERK kinase up-regulation. In conclusion, PD-L1 expression in HNSCC may be altered during cisplatin treatment, activating the MAPK/ERK kinase pathway. | - |
dc.language | 영어 | - |
dc.publisher | Impact Journals | - |
dc.title | Changes in programmed death-ligand 1 expression during cisplatin treatment in patients with head and neck squamous cell carcinoma | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 전윤경 | - |
dc.contributor.AlternativeAuthor | 김동완 | - |
dc.contributor.AlternativeAuthor | 정경천 | - |
dc.contributor.AlternativeAuthor | 우홍균 | - |
dc.contributor.AlternativeAuthor | 허대석 | - |
dc.contributor.AlternativeAuthor | 성명훈 | - |
dc.contributor.AlternativeAuthor | 권성근 | - |
dc.identifier.doi | 10.18632/oncotarget.18542 | - |
dc.citation.journaltitle | Oncotarget | - |
dc.identifier.wosid | 000419392300019 | - |
dc.identifier.scopusid | 2-s2.0-85035049064 | - |
dc.citation.endpage | 97927 | - |
dc.citation.number | 58 | - |
dc.citation.startpage | 97920 | - |
dc.citation.volume | 8 | - |
dc.identifier.sci | 000419392300019 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kwon, Seong Keun | - |
dc.contributor.affiliatedAuthor | Jeon, Yoon Kyung | - |
dc.contributor.affiliatedAuthor | Jung, Kyeong Chun | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Wu, Hong-Gyun | - |
dc.contributor.affiliatedAuthor | Sung, Myung Whun | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | LOCALLY ADVANCED HEAD | - |
dc.subject.keywordPlus | PROMOTES T-CELL | - |
dc.subject.keywordPlus | PD-1 BLOCKADE | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | INDUCTION CHEMOTHERAPY | - |
dc.subject.keywordPlus | PEMBROLIZUMAB | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | RECURRENT | - |
dc.subject.keywordAuthor | programmed death-ligand 1 | - |
dc.subject.keywordAuthor | head and neck squamous cell carcinoma | - |
dc.subject.keywordAuthor | cisplatin | - |
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