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Novel JAK3-Activating Mutations in Extranodal NK/T-Cell Lymphoma, Nasal Type

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dc.contributor.authorSim, Sung Hoon-
dc.contributor.authorKim, Soyeon-
dc.contributor.authorKim, Tae Min-
dc.contributor.authorJeon, Yoon Kyung-
dc.contributor.authorNam, Soo Jeong-
dc.contributor.authorAhn, Yong-Oon-
dc.contributor.authorKeam, Bhumsuk-
dc.contributor.authorPark, Hyun Ho-
dc.contributor.authorKim, Dong-Wan-
dc.contributor.authorKim, Chul Woo-
dc.contributor.authorHeo, Dae Seog-
dc.date.accessioned2020-04-27T11:08:35Z-
dc.date.available2020-04-27T11:08:35Z-
dc.date.issued2017-05-
dc.identifier.citationAmerican Journal of Pathology, Vol.187 No.5, pp.980-986-
dc.identifier.issn0002-9440-
dc.identifier.other49102-
dc.identifier.urihttps://hdl.handle.net/10371/165259-
dc.description.abstractInhibition of the Janus kinase (JAK)-STAT pathway has been implicated as a treatment option for extranodal natural killer/T-cell lymphoma, nasal type (NTCL). However, JAK-STAT pathway alterations in NTCL are variable, and the efficacy of JAK-STAT pathway inhibition has been poorly evaluated. JAK3 mutation and STAT3 genetic alterations were investigated by direct sequencing and immunohistochemistry in 84 patients with newly diagnosed NTCL. Five of 71 patients with NTCL (7.0%) had JAK3 mutations in the pseudokinase domain: two JAK3(A573V), two JAK3(H583Y), and one JAK3(G589D) mutation. Proliferation of Ba/F3 cells transduced with novel JAK3 mutations (JAK3(H583Y) and JAK3(G589D)) was independent of IL-3 and was inhibited by the JAK3 inhibitor tofacitinib (means +/- SD drug concentration causing a 50% inhibition of the desired activity, 85 +/- 10 nmol/L and 54 +/- 9 nmol/L). Ribbon diagrams revealed that these JAK3 pseudokinase domain mutations were located at the pseudokinase-kinase domain interface. Although phosphorylated STAT3 was overexpressed in 35 of 68 patients with NTCL (51.4%), a STAT3 mutation (p.Tyr640Phe; STAT3(Y640F)) at the SRC homology 2 domain was detected in 1 of the 63 patients (1.5%). A STAT3 inhibitor was active against STAT3-mutant SNK-6 and YT cells. Novel JAK3 mutations are oncogenic and druggable in NTCL. The JAK3 or STAT3 signal was altered in NTCL, and pathway inhibition might be a therapeutic option for patients with JAK3- or STAT3-mutant NTCL.-
dc.titleNovel JAK3-Activating Mutations in Extranodal NK/T-Cell Lymphoma, Nasal Type-
dc.typeArticle-
dc.contributor.AlternativeAuthor김철우-
dc.contributor.AlternativeAuthor전윤경-
dc.contributor.AlternativeAuthor김동완-
dc.contributor.AlternativeAuthor허대석-
dc.identifier.doi10.1016/j.ajpath.2017.01.004-
dc.citation.journaltitleAmerican Journal of Pathology-
dc.identifier.scopusid2-s2.0-85019045647-
dc.citation.endpage986-
dc.citation.number5-
dc.citation.startpage980-
dc.citation.volume187-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0002944017302110?via%3Dihub-
dc.identifier.rimsid49102-
dc.identifier.sci000400229600005-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Dong-Wan-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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