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Prognostic Impact of Newly Proposed M Descriptors in TNM Classification of Non-Small Cell Lung Cancer

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dc.contributor.authorShin, Junghoon-
dc.contributor.authorKeam, Bhumsuk-
dc.contributor.authorKim, Miso-
dc.contributor.authorPark, Young Sik-
dc.contributor.authorKim, Tae Min-
dc.contributor.authorKim, Dong-Wan-
dc.contributor.authorKim, Young Whan-
dc.contributor.authorHeo, Dae Seog-
dc.date.accessioned2020-04-27T11:09:47Z-
dc.date.available2020-04-27T11:09:47Z-
dc.date.issued2017-03-
dc.identifier.citationJournal of Thoracic Oncology, Vol.12 No.3, pp.520-528-
dc.identifier.issn1556-0864-
dc.identifier.other44673-
dc.identifier.urihttps://hdl.handle.net/10371/165265-
dc.description.abstractIntroduction: The International Association for the Study of Lung Cancer recently proposed new M descriptors for the next edition of the TNM classification for NSCLC, subdividing the current M1b category into two subcategories: M1b, which indicates a solitary extrathoracic metastasis in a single organ, and M1c, which indicates multiple extrathoracic metastasis. The purpose of this study was to validate the prognostic value of the newly proposed M descriptors in an independent cohort with multivariate and subgroup analysis. Methods: A total of 1024 patients in a consecutive lung cancer database who had stage IV NSCLC treated between 2011 and 2014 were analyzed. Newly proposed M staging was used for classification and comparison of survival. Adjustment for other clinical covariates and subgroup analysis was conducted. Results: According to the newly proposed M descriptors, 262 patients (25.6%), 152 patients (14.8%), and 610 patients (59.6%) were classified into the subgroups M1a, M1b, and M1c, respectively. The median overall survival times were 22.5, 17.8, and 13.6 months for the M1a, M1b, and M1c groups, respectively (p < 0.001). After adjustment for other covariates, Cox proportional hazards regression revealed statistically significantly shorter overall survival for the M1b group than for the M1a group (hazard ratio = 1.30; 95% confidence interval: 1.03-1.65, p = 0.03) and for the M1c than the M1b group (hazard ratio = 1.57; 95% confidence interval: 1.28-1.93, p < 0.001). These differences showed a consistent tendency regardless of pathologic and molecular subtypes. Conclusions: The newly proposed M descriptors have prognostic value in patients with stage IV NSCLC. (C) 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.-
dc.subjectNSCLC-
dc.subjectTNM staging-
dc.subjectExternal validation-
dc.subjectPrognosis-
dc.titlePrognostic Impact of Newly Proposed M Descriptors in TNM Classification of Non-Small Cell Lung Cancer-
dc.typeArticle-
dc.contributor.AlternativeAuthor김동완-
dc.contributor.AlternativeAuthor허대석-
dc.contributor.AlternativeAuthor김영환-
dc.identifier.doi10.1016/j.jtho.2016.11.2216-
dc.citation.journaltitleJournal of Thoracic Oncology-
dc.identifier.scopusid2-s2.0-85015332945-
dc.citation.endpage528-
dc.citation.number3-
dc.citation.startpage520-
dc.citation.volume12-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1556086416334578?via%3Dihub-
dc.identifier.rimsid44673-
dc.identifier.sci000396975500012-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Dong-Wan-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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