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Prognostic Impact of Newly Proposed M Descriptors in TNM Classification of Non-Small Cell Lung Cancer
DC Field | Value | Language |
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dc.contributor.author | Shin, Junghoon | - |
dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Kim, Miso | - |
dc.contributor.author | Park, Young Sik | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.date.accessioned | 2020-04-27T11:09:47Z | - |
dc.date.available | 2020-04-27T11:09:47Z | - |
dc.date.created | 2018-08-20 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.citation | Journal of Thoracic Oncology, Vol.12 No.3, pp.520-528 | - |
dc.identifier.issn | 1556-0864 | - |
dc.identifier.other | 44673 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165265 | - |
dc.description.abstract | Introduction: The International Association for the Study of Lung Cancer recently proposed new M descriptors for the next edition of the TNM classification for NSCLC, subdividing the current M1b category into two subcategories: M1b, which indicates a solitary extrathoracic metastasis in a single organ, and M1c, which indicates multiple extrathoracic metastasis. The purpose of this study was to validate the prognostic value of the newly proposed M descriptors in an independent cohort with multivariate and subgroup analysis. Methods: A total of 1024 patients in a consecutive lung cancer database who had stage IV NSCLC treated between 2011 and 2014 were analyzed. Newly proposed M staging was used for classification and comparison of survival. Adjustment for other clinical covariates and subgroup analysis was conducted. Results: According to the newly proposed M descriptors, 262 patients (25.6%), 152 patients (14.8%), and 610 patients (59.6%) were classified into the subgroups M1a, M1b, and M1c, respectively. The median overall survival times were 22.5, 17.8, and 13.6 months for the M1a, M1b, and M1c groups, respectively (p < 0.001). After adjustment for other covariates, Cox proportional hazards regression revealed statistically significantly shorter overall survival for the M1b group than for the M1a group (hazard ratio = 1.30; 95% confidence interval: 1.03-1.65, p = 0.03) and for the M1c than the M1b group (hazard ratio = 1.57; 95% confidence interval: 1.28-1.93, p < 0.001). These differences showed a consistent tendency regardless of pathologic and molecular subtypes. Conclusions: The newly proposed M descriptors have prognostic value in patients with stage IV NSCLC. (C) 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier Inc. | - |
dc.title | Prognostic Impact of Newly Proposed M Descriptors in TNM Classification of Non-Small Cell Lung Cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김동완 | - |
dc.contributor.AlternativeAuthor | 허대석 | - |
dc.contributor.AlternativeAuthor | 김영환 | - |
dc.identifier.doi | 10.1016/j.jtho.2016.11.2216 | - |
dc.citation.journaltitle | Journal of Thoracic Oncology | - |
dc.identifier.wosid | 000396975500012 | - |
dc.identifier.scopusid | 2-s2.0-85015332945 | - |
dc.citation.endpage | 528 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 520 | - |
dc.citation.volume | 12 | - |
dc.identifier.sci | 000396975500012 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Kim, Young Whan | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FORTHCOMING 7TH EDITION | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | STAGING PROJECT | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | BRAIN METASTASES | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | RADIOSURGERY | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordAuthor | NSCLC | - |
dc.subject.keywordAuthor | TNM staging | - |
dc.subject.keywordAuthor | External validation | - |
dc.subject.keywordAuthor | Prognosis | - |
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