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The effect of induction chemotherapy using docetaxel, cisplatin, and fluorouracil on survival in locally advanced head and neck squamous cell carcinoma: A meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Kim, Ryul | - |
dc.contributor.author | Hahn, Seokyung | - |
dc.contributor.author | Shin, Junghoon | - |
dc.contributor.author | Ock, Chan-Young | - |
dc.contributor.author | Kim, Miso | - |
dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.date.accessioned | 2020-04-27T11:12:05Z | - |
dc.date.available | 2020-04-27T11:12:05Z | - |
dc.date.created | 2018-09-04 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.citation | Cancer Research and Treatment, Vol.48 No.3, pp.907-916 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.other | 50075 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165284 | - |
dc.description.abstract | Purpose The purpose of this study was to compare the survival of patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) undergoing concurrent chemoradiotherapy (CRT) alone with that of patients undergoing induction chemotherapy (IC) using docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by CRT. Materials and Methods A search of the PubMed, EMBASE, and Cochrane Library databases was performed in April 2015 and abstracts from the American Society of Clinical Oncology meetings (2008-2014) were reviewed. Summaries of the results were pooled using a fixed-effect model, and the risk of bias was evaluated using the Cochrane tool. Results A total of six relevant trials comprising 1,280 patients were identified. There was no statistically significant overall survival (OS) advantage for TPF prior to CRT (TPF/CRT) over CRT alone (hazard ratio [HR] 0.92; 95% confidence interval [CI], 0.79 to 1.09; p=0.339). Progression-free survival (PFS) was significantly longer in the TPF/CRT arms (HR, 0.82; 95% CI, 0.70 to 0.95; p=0.009). Patients with non-oropharyngeal LA-HNSCC obtained the greatest OS and PFS benefits from TPF (HR, 0.68; 95% CI, 0.47 to 0.99; p=0.043 and HR, 0.67; 95% CI, 0.48 to 0.94; p=0.022, respectively). The complete response rate was significantly increased (risk ratio [RR], 1.34; 95% CI, 1.14 to 1.56; p < 0.001), and the distant metastasis rate tended to decrease (RR, 0.65; 95% CI, 0.40 to 1.04; p=0.071) in the TPF/CRT arms. Conclusion IC with TPF followed by CRT is not superior to CRT alone for OS. However, PFS and the complete response rate were significantly improved in the TPF/CRT arms. TPF/CRT for patients with nonoropharyngeal LA-HNSCC provided clear survival advantages. | - |
dc.language | 영어 | - |
dc.publisher | 대한암학회 | - |
dc.title | The effect of induction chemotherapy using docetaxel, cisplatin, and fluorouracil on survival in locally advanced head and neck squamous cell carcinoma: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김동완 | - |
dc.contributor.AlternativeAuthor | 한서경 | - |
dc.contributor.AlternativeAuthor | 허대석 | - |
dc.identifier.doi | 10.4143/crt.2015.359 | - |
dc.citation.journaltitle | Cancer Research and Treatment | - |
dc.identifier.wosid | 000380496900005 | - |
dc.identifier.scopusid | 2-s2.0-84981311950 | - |
dc.citation.endpage | 916 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 907 | - |
dc.citation.volume | 48 | - |
dc.identifier.sci | 000380496900005 | - |
dc.identifier.kciid | ART002127283 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Hahn, Seokyung | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PHASE-III | - |
dc.subject.keywordPlus | UNRESECTABLE HEAD | - |
dc.subject.keywordPlus | CONCURRENT CHEMORADIOTHERAPY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | OROPHARYNGEAL | - |
dc.subject.keywordPlus | BIAS | - |
dc.subject.keywordAuthor | Head and neck neoplasms | - |
dc.subject.keywordAuthor | Induction chemotherapy | - |
dc.subject.keywordAuthor | Chemoradiotherapy | - |
dc.subject.keywordAuthor | Review | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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