S-Space College of Medicine/School of Medicine (의과대학/대학원) Cancer Research Institute (암연구소) Journal Papers (저널논문_암연구소)
Effect of induction chemotherapy on survival in locally advanced head and neck squamous cell carcinoma treated with concurrent chemoradiotherapy: Single center experience
- Ock, Chan-Young; Keam, Bhumsuk; Lim, Yoojoo; Kim, Tae Min; Lee, Se-Hoon; Kwon, Seong Keun; Hah, J. Hun; Kwon, Tack-Kyun; Kim, Dong-Wan; Wu, Hong-Gyun; Sung, Myung-Whun; Heo, Dae Seog
- Issue Date
- Head and Neck, Vol.38 No.2, pp.277-284
- induction chemotherapy; concurrent chemoradiotherapy; head and neck cancer; survival; subgroup analysis
- BackgroundAlthough induction chemotherapy can reduce distant metastases in locally advanced head and neck squamous cell carcinoma (HNSCC), overall survival (OS) improvement because of induction chemotherapy has not been confirmed. MethodsWe reviewed medical records of 224 patients diagnosed with locally advanced HNSCC who were treated with induction chemotherapy followed by concurrent chemoradiotherapy (CRT; induction chemotherapy/CRT; N = 144) and CRT alone (N = 80) from 2005 to 2013. We analyzed OS and progression-free survival (PFS). ResultsThe 3-year OS rate was significantly higher in the induction chemotherapy/CRT group compared to the CRT group (74.0% vs 62.7%; p = .045). The 3-year PFS rate was 64.6% in the induction chemotherapy/CRT group and 54.1% in the CRT group (p = .060). Subgroup analysis showed patients with high N classification (N2 or N3) oropharyngeal cancer had greater benefits when treated with induction chemotherapy/CRT. ConclusionInduction chemotherapy plus CRT improved OS, compared to CRT alone in locally advanced HNSCC, especially with high N classification. (c) 2015 Wiley Periodicals, Inc. Head Neck 38: 277-284, 2016
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