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Neutrophil to lymphocyte ratio improves prognostic prediction of International Prognostic Index for patients with diffuse large B-cell lymphoma treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone
DC Field | Value | Language |
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dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Ha, Hyerim | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.contributor.author | Lee, Se-Hoon | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Kim, Chul Woo | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.date.accessioned | 2020-04-27T11:21:23Z | - |
dc.date.available | 2020-04-27T11:21:23Z | - |
dc.date.created | 2018-10-22 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.citation | Leukemia and Lymphoma, Vol.56 No.7, pp.2032-2038 | - |
dc.identifier.issn | 1042-8194 | - |
dc.identifier.other | 61811 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165376 | - |
dc.description.abstract | The purpose of this study was to analyze the pre- and post-treatment neutrophil to lymphocyte ratio (pre- and post-NLR) in combination with immunologic profiles in patients with diffuse large B-cell lymphoma (DLBCL) treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). A total of 447 newly diagnosed patients with DLBCL treated with R-CHOP were analyzed retrospectively. A pre-NLR >= 3 was independently associated with poor progression-free survival (PFS) (hazard ratio [FIR] = 2.19, p <0.001) and overall survival (OS) (HR = 2.89, p<0.001). In patients with high pre-NLR, reduction of the post-NLR to <3 after R-CHOP was correlated with improved survival. Low pre-NLR (<3) was also associated with a higher number of peripheral CD19 + lymphocytes (p = 0.049) and NK cells (p = 0.031). In conclusion, a pre-NLR >= 3 was an independent prognostic factor for PFS and OS in patients with DLBCL treated with R-CHOP. | - |
dc.language | 영어 | - |
dc.publisher | Taylor & Francis | - |
dc.title | Neutrophil to lymphocyte ratio improves prognostic prediction of International Prognostic Index for patients with diffuse large B-cell lymphoma treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 허대석 | - |
dc.contributor.AlternativeAuthor | 김철우 | - |
dc.contributor.AlternativeAuthor | 전윤경 | - |
dc.contributor.AlternativeAuthor | 김동완 | - |
dc.identifier.doi | 10.3109/10428194.2014.982642 | - |
dc.citation.journaltitle | Leukemia and Lymphoma | - |
dc.identifier.wosid | 000359888700019 | - |
dc.identifier.scopusid | 2-s2.0-84938061525 | - |
dc.citation.endpage | 2038 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 2032 | - |
dc.citation.volume | 56 | - |
dc.identifier.sci | 000359888700019 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Jeon, Yoon Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Kim, Chul Woo | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | R-CHOP | - |
dc.subject.keywordPlus | IPI | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | MODELS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ERA | - |
dc.subject.keywordAuthor | Neutrophil to lymphocyte ratio | - |
dc.subject.keywordAuthor | diffuse large B-cell lymphoma | - |
dc.subject.keywordAuthor | prognosis | - |
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