S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Clinical Implications of VEGF, TGF-beta 1, and IL-1 beta in Patients with Advanced Non-small Cell Lung Cancer
- Kim, Ji-Won; Koh, Youngil; Kim, Dong-Wan; Ahn, Yong-Oon; Kim, Tae Min; Han, Sae-Won; Oh, Do-Youn; Lee, Se-Hoon; Im, Seock-Ah; Kim, Tae-You; Heo, Dae Seog; Bang, Yung-Jue
- Issue Date
- Cancer Research and Treatment, Vol.45 No.4, pp.325-333
- Vascular endothelial growth factor; Interleukin-1beta; Transforming growth factor beta1; Leukocytes; Blood platelets; Non-small cell lung carcinoma
- Purpose Vascular endothelial growth factor (VEGF)-A, VEGF(165)b, interleukin (IL)-1 beta, and transforming growth factor (TGF)-beta 1 are known to influence tumor angiogenesis. Clinical implications of these cytokines need to be elucidated. Materials and Methods Using clinical data and baseline serum samples of 140 consecutive patients with advanced non-small cell lung cancer who received platinum-based combination chemotherapy, we investigated the association among serum cytokine levels, treatment outcomes, as well as leukocyte and platelet counts. Results The median age of patients was 64 years (range, 26 to 86 years). The male to female ratio was 104:36. High TGF-beta 1 and IL-1 beta levels were associated with shorter progression-free survival, and high VEGF-A and IL-1 beta levels were associated with shorter overall survival in the univariate analysis. VEGF(165)b was not related to the treatment outcomes. Leukocytosis and thrombocytosis were associated with shorter overall survival. The multivariate analysis demonstrated that VEGF-A, IL-1 beta, and leukocytosis were significant prognostic factors (p=0.0497, p=0.047, and p<0.001, respectively). Leukocytosis was not associated with recent pneumonia (p=0.937) and correlated with VEGF-A (p<0.001) and TGF-beta 1 (p=0.020) levels. Conclusion Serum VEGF-A, TGF-1 beta, and IL-1 beta levels, in addition to leukocyte and platelet counts, are shown to be associated with clinical outcomes. Leukocyte and platelet counts are correlated with serum VEGF-A and TGF-beta 1 levels.