Browse

Association of oral mucositis with quality of life and symptom clusters in patients with solid tumors receiving chemotherapy

Cited 14 time in Web of Science Cited 16 time in Scopus
Authors
Kim, Jin Won; Cha, Yongjun; Kim, Su-Jung; Han, Sae-Won; Oh, Do-Youn; Lee, Se-Hoon; Kim, Dong-Wan; Im, Seock-Ah; Kim, Tae-You; Heo, Dae Seog; Bang, Yung-Jue
Issue Date
2012-02
Citation
Supportive Care in Cancer, Vol.20 No.2, pp.395-403
Keywords
Oral mucositisChemotherapyAdverse effectQuality of lifeSymptom clusters
Abstract
The study aims to determine whether or not oral mucositis (OM) during active chemotherapy in patients with solid tumors is representative of the patient's quality of life (QOL) and the suffering from adverse effects. From October 2007 to September 2008, we prospectively enrolled 344 consecutive patients with solid tumors who initiated a new chemotherapy regimen. OM, other adverse effects, and the QOL were surveyed by face-to-face interviews and patient diaries. OM developed during 175 of 633 cycles (27.7%). Forty-five percent of the patients experienced OM during two cycles of chemotherapy. The QOL in patients with OM was significantly lower than patients without OM, as evaluated by the Functional Assessment of Cancer Therapy-General (70.26 +/- 15.36 and 75.09 +/- 13.12, respectively; p < 0.001). Specifically, the physical and emotional well-being was lower in patients with OM compared with patients without OM. Moreover, other adverse effects were more frequent in chemotherapy cycles with OM compared with chemotherapy cycles without OM (amount of food intake, activity, nausea, vomiting, fever, myalgias, and sensory neuropathy; p < 0.001, p = 0.008, p < 0.001, p = 0.001, p = 0.002, p < 0.001, and p < 0.001, respectively). OM represents poor QOL and is a basic symptom of symptom clusters in patients with solid tumors receiving active chemotherapy.
ISSN
0941-4355
URI
https://hdl.handle.net/10371/165492
DOI
https://doi.org/10.1007/s00520-011-1126-8
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse