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The Lack of CD34 Expression in Gastrointestinal Stromal Tumors is Related to Cystic Degeneration Following Imatinib Use

Cited 8 time in Web of Science Cited 7 time in Scopus

Koh, Youngil; Lee, Hee Eun; Oh, Do-Youn; Kim, Jee Hyun; Lee, Se-Hoon; Kim, Se Hyung; Kim, Dong-WanIm, Seock-Ah; Kim, Tae-You; Heo, Dae Seog; Kim, Woo-Ho; Bang, Yung-Jue

Issue Date
Oxford University Press
Japanese Journal of Clinical Oncology, Vol.42 No.11, pp.1020-1027
We evaluated the characteristics of the gastrointestinal stromal tumors that showed discrepancies between their assessment using the Response Evaluation Criteria in Solid Tumor (RECIST) and Chois criteria. We also investigated the clinical applicability of Chois criteria to Korean gastrointestinal stromal tumor patients undergoing imatinib therapy. Patients with advanced gastrointestinal stromal tumors treated with frontline imatinib were analyzed. Computed tomography images of these patients were reviewed and genotyping for the KIT and PDGFRA genes was performed. Immunohistochemical staining of c-KIT, CD34, platelet derived growth factor receptor-alpha, platelet derived growth factor receptor-beta, AKT, P-ERK and vascular endothelial growth factor was followed. Ninety-five patients were enrolled. When using Chois criteria to evaluate the 61 patients who achieved at least partial response by Chois criteria, 27 patients showed discrepancies in their response to treatment between these two sets of criteria. A lack of CD34 expression in tumors was found to be related to cystic degeneration after imatinib treatment (P 0.001). Patients who showed partial response by Chois criteria but stable disease by RECIST criteria had a similar progression-free survival to cases who showed a partial response under both systems (P 0.951). Gastrointestinal stromal tumors showing cystic degeneration after imatinib treatment lack CD34 expression. Chois criteria have a clinical value in terms of the progression-free survival in Korean patients treated with imatinib.
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  • College of Medicine
  • Department of Medicine
Research Area Clinical Medicine


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