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Clinical significance of tumor-infiltrating FOXP3+T cells in patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma

Cited 5 time in Web of Science Cited 7 time in Scopus
Authors
Kim, Ki Hwan; Kim, Tae Min; Go, Heounjeong; Kim, Wook Youn; Jeon, Yoon Kyung; Lee, Se-Hoon; Kim, Dong-Wan; Khwarg, Sang In; Kim, Chul Woo; Heo, Dae Seog
Issue Date
2011-11
Citation
Cancer Science, Vol.102 No.11, pp.1972-1976
Abstract
We evaluated the association between tumor-infiltrating FOXP3+ T cells and clinical outcomes in patients with ocular adnexal lymphoma of mucosa-associated lymphoid tissue type (OAML). Pretreatment formalin-fixed paraffin-embedded tissues from 42 patients with OAML were stained with 236A/E7 anti-FOXP3 murine monoclonal antibody as well as CD3, CD4 and CD8 antibodies. The amount of FOXP3+ T cells was numerically quantified using an image analysis program. Front-line treatments were as follows: combination chemotherapy (n = 25); radiotherapy (n = 9); doxycycline (n = 6); and wait and see (n = 2). Complete response (CR) was observed in 20 (50%) of 40 evaluable patients. Median progression-free survival (PFS) was 50 months. A high number of FOXP3+ T cells (n = 21, >= 180/0.58 mm(2)) showed a higher CR rate (33% vs 71%, P = 0.013) and tendency towards prolonged PFS (48 vs 67 months, P = 0.110). In the combination chemotherapy group, a high number of FOXP3+ T cells was significantly associated with a higher CR rate (29% vs 82%, P = 0.008) and prolonged PFS (17 vs 79 months, P = 0.003). A high number of tumor-infiltrating FOXP3+ T cells correlates with a favorable clinical outcome in OAML patients. (Cancer Sci 2011; 102: 1972-1976)
ISSN
1347-9032
URI
http://hdl.handle.net/10371/165526
DOI
https://doi.org/10.1111/j.1349-7006.2011.02051.x
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College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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