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Cas-Designer: a web-based tool for choice of CRISPR-Cas9 target sites
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Park, Jeongbin | - |
| dc.contributor.author | Bae, Sangsu | - |
| dc.contributor.author | Kim, Jin-Soo | - |
| dc.date.accessioned | 2020-04-27T12:44:40Z | - |
| dc.date.available | 2020-04-27T12:44:40Z | - |
| dc.date.created | 2018-09-19 | - |
| dc.date.created | 2018-09-19 | - |
| dc.date.issued | 2015-12 | - |
| dc.identifier.citation | Bioinformatics, Vol.31 No.24, pp.4014-4016 | - |
| dc.identifier.issn | 1367-4803 | - |
| dc.identifier.other | 55458 | - |
| dc.identifier.uri | https://hdl.handle.net/10371/165655 | - |
| dc.description.abstract | We present Cas-Designer, a user-friendly program to aid researchers in choosing appropriate target sites in a gene of interest for type II CRISPR/Cas-derived RNA-guided endonucleases, which are now widely used for biomedical research and biotechnology. Cas-Designer rapidly provides the list of all possible guide RNA sequences in a given input DNA sequence and their potential off-target sites including bulge-type sites in a genome of choice. In addition, the program assigns an out-of-frame score to each target site to help users choose appropriate sites for gene knockout. Cas-Designer shows the results in an interactive table and provides user-friendly filter functions. | - |
| dc.language | 영어 | - |
| dc.publisher | Oxford University Press | - |
| dc.title | Cas-Designer: a web-based tool for choice of CRISPR-Cas9 target sites | - |
| dc.type | Article | - |
| dc.contributor.AlternativeAuthor | 김진수 | - |
| dc.identifier.doi | 10.1093/bioinformatics/btv537 | - |
| dc.citation.journaltitle | Bioinformatics | - |
| dc.identifier.wosid | 000366630400024 | - |
| dc.identifier.scopusid | 2-s2.0-84950292610 | - |
| dc.citation.endpage | 4016 | - |
| dc.citation.number | 24 | - |
| dc.citation.startpage | 4014 | - |
| dc.citation.volume | 31 | - |
| dc.identifier.sci | 000366630400024 | - |
| dc.description.isOpenAccess | Y | - |
| dc.contributor.affiliatedAuthor | Kim, Jin-Soo | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.subject.keywordPlus | RNA-GUIDED ENDONUCLEASES | - |
| dc.subject.keywordPlus | NUCLEASES | - |
| dc.subject.keywordPlus | CRISPR/CAS9 | - |
| dc.subject.keywordPlus | SYSTEMS | - |
| dc.subject.keywordPlus | CELLS | - |
| dc.subject.keywordPlus | DNA | - |
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