Publications
Detailed Information
A homozygous Keap1-knockout human embryonic stem cell line generated using CRISPR/Cas9 mediates gene targeting
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, So-Jung | - |
dc.contributor.author | Habib, Omer | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.contributor.author | Han, Hyo-Won | - |
dc.contributor.author | Koo, Soo Kyung | - |
dc.contributor.author | Kim, Jung-Hyun | - |
dc.date.accessioned | 2020-04-27T12:53:22Z | - |
dc.date.available | 2020-04-27T12:53:22Z | - |
dc.date.created | 2018-08-16 | - |
dc.date.created | 2018-08-16 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.citation | Stem Cell Research, Vol.19, pp.52-54 | - |
dc.identifier.issn | 1873-5061 | - |
dc.identifier.other | 43975 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165684 | - |
dc.description.abstract | Kelch-like ECH-associated protein 1 (keap1) is a cysteine-rich protein that interacts with transcription factor Nrf2 in a redox-sensitive manner, leading to the degradation of Nrf2 (Kim et al., 2014a). Disruption of Keap1 results in the induction of Nrf2-related signaling pathways involving the expression of a set of anti-oxidant and anti-inflammatory genes. We generated biallelic mutants of the Keap1 gene using a CRISPR-Cas9 genome editing method in the H9 human embryonic stem cell (hESC). The Keap1 homozygous-knockout H9 cell line retained normal morphology, gene expression, and in vivo differentiation potential. (C) 2016 The Author(s). Published by Elsevier B.V. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier | - |
dc.title | A homozygous Keap1-knockout human embryonic stem cell line generated using CRISPR/Cas9 mediates gene targeting | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김진수 | - |
dc.identifier.doi | 10.1016/j.scr.2016.12.028 | - |
dc.citation.journaltitle | Stem Cell Research | - |
dc.identifier.wosid | 000397450700012 | - |
dc.identifier.scopusid | 2-s2.0-85020318911 | - |
dc.citation.endpage | 54 | - |
dc.citation.startpage | 52 | - |
dc.citation.volume | 19 | - |
dc.identifier.sci | 000397450700012 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.