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Precision genome engineering through adenine base editing in plants
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Beum-Chang | - |
dc.contributor.author | Yun, Jae-Young | - |
dc.contributor.author | Kim, Sang-Tae | - |
dc.contributor.author | Shin, YouJin | - |
dc.contributor.author | Ryu, Jahee | - |
dc.contributor.author | Choi, Minkyung | - |
dc.contributor.author | Woo, Je Wook | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.date.accessioned | 2020-04-27T12:58:44Z | - |
dc.date.available | 2020-04-27T12:58:44Z | - |
dc.date.created | 2019-08-13 | - |
dc.date.created | 2019-08-13 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.citation | Nature Plants, Vol.4 No.7, pp.427-431 | - |
dc.identifier.issn | 2055-026X | - |
dc.identifier.other | 80820 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165699 | - |
dc.description.abstract | The recent development of adenine base editors (ABEs) has enabled efficient and precise A-to-G base conversions in higher eukaryotic cells. Here, we show that plant-compatible ABE systems can be successfully applied to protoplasts of Arabidopsis thaliana and Brassica napus through transient transfection, and to individual plants through Agrobacterium-mediated transformation to obtain organisms with desired phenotypes. Targeted, precise A-to-G substitutions generated a single amino acid change in the FT protein or missplicing of the PDS3 RNA transcript, and we could thereby obtain transgenic plants with late-flowering and albino phenotypes, respectively. Our results provide 'proof of concept' for in planta ABE applications that can lead to induced neo-functionalization or altered mRNA splicing, opening up new avenues for plant genome engineering and biotechnology. | - |
dc.language | 영어 | - |
dc.publisher | Palgrave Macmillan Ltd. | - |
dc.title | Precision genome engineering through adenine base editing in plants | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김진수 | - |
dc.identifier.doi | 10.1038/s41477-018-0178-x | - |
dc.citation.journaltitle | Nature Plants | - |
dc.identifier.wosid | 000443221200014 | - |
dc.identifier.scopusid | 2-s2.0-85048029625 | - |
dc.citation.endpage | 431 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 427 | - |
dc.citation.volume | 4 | - |
dc.identifier.sci | 000443221200014 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ARABIDOPSIS | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | WHEAT | - |
dc.subject.keywordPlus | RICE | - |
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