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Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target

Cited 32 time in Web of Science Cited 28 time in Scopus
Issue Date
2019-03
Citation
Nature Communications, Vol.10, p. 1111
Abstract
Activated macrophages have the potential to be ideal targets for imaging inflammation. However, probe selectivity over non-activated macrophages and probe delivery to target tissue have been challenging. Here, we report a small molecule probe specific for activated macrophages, called CDg16, and demonstrate its application to visualizing inflammatory atherosclerotic plaques in vivo. Through a systematic transporter screen using a CRISPR activation library, we identify the orphan transporter Slc18b1/SLC18B1 as the gating target of CDg16.
ISSN
2041-1723
URI
https://hdl.handle.net/10371/165714
DOI
https://doi.org/10.1038/s41467-019-08990-9
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