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Comparative Genomic Analysis of the 2016 Vibrio cholerae Outbreak in South Korea

Cited 4 time in Web of Science Cited 5 time in Scopus
Issue Date
2019-08
Citation
Frontiers in Public Health, Vol.7, p. 228
Keywords
choleraVibrio choleraegenome sequencingmolecular epidemiologycomparative genomics analysis
Abstract
In August 2016, South Korea experienced a cholera outbreak that caused acute watery diarrhea in three patients. This outbreak was the first time in 15 years that an outbreak was not linked to an overseas source. To identify the cause and to study the epidemiological implications of this outbreak, we sequenced the whole genome of Vibrio cholerae isolates; three from each patient and one from a seawater sample. Herein we present comparative genomic data which reveals that the genome sequences of these four isolates are very similar. Interestingly, these isolates form a monophyletic Glade with V. cholerae strains that caused an outbreak in the Philippines in 2011. The V. cholerae strains responsible for the Korean and Philippines outbreaks have almost identical genomes in which two unique genomic islands are shared, and they both lack SXT elements. Furthermore, we confirm that seawater is the likely source of this outbreak, which suggests the necessity for future routine surveillance of South Korea's seashore.
ISSN
2296-2565
URI
https://hdl.handle.net/10371/165722
DOI
https://doi.org/10.3389/fpubh.2019.00228
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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