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Evidence for several waves of global transmission in the seventh cholera pandemic

Cited 364 time in Web of Science Cited 385 time in Scopus
Authors
Mutreja, Ankur; Kim, Dong Wook; Thomson, Nicholas R.; Connor, Thomas R.; Lee, Je Hee; Kariuki, Samuel; Croucher, Nicholas J.; Choi, Seon Young; Harris, Simon R.; Lebens, Michael; Niyogi, Swapan Kumar; Kim, Eun Jin; Ramamurthy, T.; Chun, Jongsik; Wood, James L. N.; Clemens, John D.; Czerkinsky, Cecil; Nair, G. Balakrish; Holmgren, Jan; Parkhill, Julian; Dougan, Gordon
Issue Date
2011-09
Citation
Nature, Vol.477 No.7365, pp.462-U111
Abstract
Vibrio cholerae is a globally important pathogen that is endemic in many areas of the world and causes 3-5 million reported cases of cholera every year. Historically, there have been seven acknowledged cholera pandemics; recent outbreaks in Zimbabwe and Haiti are included in the seventh and ongoing pandemic(1). Only isolates in serogroup O1 (consisting of two biotypes known as 'classical' and 'El Tor') and the derivative O139 (refs 2, 3) can cause epidemic cholera(2). It is believed that the first six cholera pandemics were caused by the classical biotype, but El Tor has subsequently spread globally and replaced the classical biotype in the current pandemic(1). Detailed molecular epidemiological mapping of cholera has been compromised by a reliance on sub-genomic regions such as mobile elements to infer relationships, making El Tor isolates associated with the seventh pandemic seem superficially diverse. To understand the underlying phylogeny of the lineage responsible for the current pandemic, we identified high-resolution markers (single nucleotide polymorphisms; SNPs) in 154 whole-genome sequences of globally and temporally representative V. cholerae isolates. Using this phylogeny, we show here that the seventh pandemic has spread from the Bay of Bengal in at least three independent but overlapping waves with a common ancestor in the 1950s, and identify several transcontinental transmission events. Additionally, we show how the acquisition of the SXT family of antibiotic resistance elements has shaped pandemic spread, and show that this family was first acquired at least ten years before its discovery in V. cholerae.
ISSN
0028-0836
URI
http://hdl.handle.net/10371/165911
DOI
https://doi.org/10.1038/nature10392
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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