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Genome sequence of hybrid Vibrio cholerae O1 MJ-1236, B-33, and CIRS101 and comparative genomics with V. cholerae

Cited 67 time in Web of Science Cited 76 time in Scopus
Authors
Grim, Christopher J.; Hasan, Nur A.; Taviani, Elisa; Haley, Bradd; Chun, Jongsik; Brettin, Thomas S.; Bruce, David C.; Detter, J. Chris; Han, Cliff S.; Chertkov, Olga; Challacombe, Jean; Huq, Anwar; Nair, G. Balakrish; Colwell, Rita R.
Issue Date
2010-07
Citation
Journal of Bacteriology, Vol.192 No.13, pp.3524-3533
Abstract
The genomes of Vibrio cholerae O1 Matlab variant MJ-1236, Mozambique O1 El Tor variant B33, and altered O1 El Tor CIRS101 were sequenced. All three strains were found to belong to the phylocore group 1 clade of V. cholerae, which includes the 7th-pandemic O1 El Tor and serogroup O139 isolates, despite displaying certain characteristics of the classical biotype. All three strains were found to harbor a hybrid variant of CTX Phi and an integrative conjugative element (ICE), leading to their establishment as successful clinical clones and the displacement of prototypical O1 El Tor. The absence of strain-and group-specific genomic islands, some of which appear to be prophages and phage-like elements, seems to be the most likely factor in the recent establishment of dominance of V. cholerae CIRS101 over the other two hybrid strains.
ISSN
0021-9193
URI
https://hdl.handle.net/10371/165940
DOI
https://doi.org/10.1128/JB.00040-10
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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