Browse

Comparative analysis of growth-phase-dependent gene expression in virulent and avirulent Streptococcus pneumoniae using a high-density DNA microarray

DC Field Value Language
dc.contributor.authorKo, Kwan Soo-
dc.contributor.authorPark, Sulhee-
dc.contributor.authorOh, Won Sup-
dc.contributor.authorSuh, Ji-Yoeun-
dc.contributor.authorOh, TaeJeong-
dc.contributor.authorAhn, Sungwhan-
dc.contributor.authorChun, Jongsik-
dc.contributor.authorSong, Jae-Hoon-
dc.date.accessioned2020-04-27T13:40:33Z-
dc.date.available2020-04-27T13:40:33Z-
dc.date.issued2006-02-
dc.identifier.citationMolecules and Cells, Vol.21 No.1, pp.82-88-
dc.identifier.issn1016-8478-
dc.identifier.other91880-
dc.identifier.urihttp://hdl.handle.net/10371/166052-
dc.description.abstractThe global pattern of growth-dependent gene expression in Streptococcus pneumoniae strains was evaluated using a high-density DNA microarray. Total RNAs obtained from an avirulent S. pneumoniae strain R6 and a virulent strain AMC96-6 were used to compare the expression patterns at seven time points (2.5, 3.5, 4.5, 5.5, 6.0, 6.5, and 8.0 h). The expression profile of strain R6 changed between log and stationary growth (the Log-Stat switch). There were clear differences between the growth-dependent gene expression profiles of the virulent and avirulent pneumococcal strains in 367 of 1,112 genes. Transcripts of genes associated with bacterial competence and capsular polysaccharide formation, as well as clpP and cbpA, were higher in the virulent strain. Our data suggest that late log or early stationary phase may be the most virulent phase of S. pneumoniae.-
dc.subjectgene expression-
dc.subjectlog-stat switch-
dc.subjectmicroarray-
dc.subjectpneumococci-
dc.subjecttime-course analysis-
dc.subjectvirulence-
dc.titleComparative analysis of growth-phase-dependent gene expression in virulent and avirulent Streptococcus pneumoniae using a high-density DNA microarray-
dc.typeArticle-
dc.contributor.AlternativeAuthor천종식-
dc.citation.journaltitleMolecules and Cells-
dc.identifier.scopusid2-s2.0-33645744892-
dc.citation.endpage88-
dc.citation.number1-
dc.citation.startpage82-
dc.citation.volume21-
dc.identifier.urlhttp://www.molcells.org/journal/view.html?year=2006&volume=21&number=1&spage=82-
dc.identifier.rimsid91880-
dc.identifier.sci000235685000010-
dc.identifier.kciidART001095725-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorChun, Jongsik-
Appears in Collections:
College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse