Browse

Phylogenetic analysis of the nef gene reveals a distinctive monophyletic clade in Korean HIV-1 cases

Cited 30 time in Web of Science Cited 30 time in Scopus
Authors
Kang, Mi Ran; Cho, Young-Keol; Chun, Jongsik; Kim, Young-Bong; Lee, Im-Soon; Lee, Hee Jung; Kim, Seon Hee; Kim, Yoo-Kyum; Yoon, Keejung; Yang, Jai-Myung; Kim, June Myung; Shin, Yung-Oh; Kang, Chun; Lee, Joo Shil; Choi, Kang Won; Kim, Dae-Ghon; Fitch, Walter M.; Kim, Sunyoung
Issue Date
1998-01
Citation
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol.17 No.1, pp.58-68
Keywords
HIV-1nefmolecular epidemiologyKoreaphylogenyKorean clade
Abstract
To study the genetic variation of the HIV-1 strains prevalent in South Korea, we analyzed the nef sequences derived from 46 HIV-l-positive individuals living in various geographic regions in Korea. Phylogenetic analysis revealed four subtypes of HIV-1: A (3 patients), B (41 patients), D (I patient), and a type that could not be clearly classified to any known subtype (1 patient). Thirty-five of the 41 Korean subtype B isolates formed a distinct monophyletic clade that is not related to any of the international sequences from the Los Alamos Database or GenBank as of June 1997. Indeed, the presence of unique conserved sequences was identified among the Korean isolates in this Korean subtype B group. The variations in the nucleotide sequences of a majority (32 of 35) subtype B samples within the Korean clade were 1.9% to 8.8%, and amino acid sequences varied from 3.9% to 15.5%. These results suggest that HN-I strains currently present in South Korea might have originated from a few sources or might be developing through a certain selective pressure. This is the first report on the molecular nature of the HIV-I infection present in South Korea.
ISSN
1077-9450
URI
https://hdl.handle.net/10371/166191
DOI
https://doi.org/10.1097/00042560-199801010-00009
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse