S-Space College of Natural Sciences (자연과학대학) Dept. of Biological Sciences (생명과학부) Journal Papers (저널논문_생명과학부)
Phylogenetic analysis of the nef gene reveals a distinctive monophyletic clade in Korean HIV-1 cases
- Kang, Mi Ran; Cho, Young-Keol; Chun, Jongsik; Kim, Young-Bong; Lee, Im-Soon; Lee, Hee Jung; Kim, Seon Hee; Kim, Yoo-Kyum; Yoon, Keejung; Yang, Jai-Myung; Kim, June Myung; Shin, Yung-Oh; Kang, Chun; Lee, Joo Shil; Choi, Kang Won; Kim, Dae-Ghon; Fitch, Walter M.; Kim, Sunyoung
- Issue Date
- Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol.17 No.1, pp.58-68
- To study the genetic variation of the HIV-1 strains prevalent in South Korea, we analyzed the nef sequences derived from 46 HIV-l-positive individuals living in various geographic regions in Korea. Phylogenetic analysis revealed four subtypes of HIV-1: A (3 patients), B (41 patients), D (I patient), and a type that could not be clearly classified to any known subtype (1 patient). Thirty-five of the 41 Korean subtype B isolates formed a distinct monophyletic clade that is not related to any of the international sequences from the Los Alamos Database or GenBank as of June 1997. Indeed, the presence of unique conserved sequences was identified among the Korean isolates in this Korean subtype B group. The variations in the nucleotide sequences of a majority (32 of 35) subtype B samples within the Korean clade were 1.9% to 8.8%, and amino acid sequences varied from 3.9% to 15.5%. These results suggest that HN-I strains currently present in South Korea might have originated from a few sources or might be developing through a certain selective pressure. This is the first report on the molecular nature of the HIV-I infection present in South Korea.
- Files in This Item: There are no files associated with this item.