S-Space College of Medicine/School of Medicine (의과대학/대학원) Ophthalmology (안과학전공) Journal Papers (저널논문_안과학전공)
Short term effects of topical cyclosporine and viscoelastic on the ocular surfaces in patients with dry eye
- Moon, Jun Woong; Lee, Hyun Joo; Shin, Ki Chul; Wee, Won Ryang; Lee, Jin Hak; Kim, Mee Kum
- Issue Date
- Korean Journal of Ophthalmology
- Korean J Ophthalmol. 2007 Dec;21(4):189-94.
- Adjuvants, Immunologic/administration & dosage; Administration, Topical; Cell Count; Chondroitin Sulfates/*administration & dosage; Conjunctiva/drug effects/pathology; Cyclosporine/*administration & dosage; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Dry Eye Syndromes/*drug therapy/metabolism/pathology; Epithelium/drug effects/pathology; Female; Follow-Up Studies; Goblet Cells/drug effects/pathology; Humans; Hyaluronic Acid/*administration & dosage; Immunosuppressive Agents/*administration & dosage; Male; Middle Aged; Ophthalmic Solutions/administration & dosage; Tears/drug effects/metabolism; Time Factors; Treatment Outcome
- PURPOSE: To compare the short term effects of topical 0.05% cyclosporine (CsA) and a mixture of 0.08% chondroitin sulfate and 0.06% sodium hyaluronate (CS-HA) on dry eye ocular surfaces. METHODS: 36 patients with moderate to severe dry eye (5 mm/5 min or less with Schirmer's test or tear break up time (BUT) less than 6 seconds), were treated with topical application of CS-HA on one eye and CsA on the other 4 times a day for 6-8 weeks. BUT, Schirmer's test without anesthesia, and conjunctival impression cytology (CIC; goblet cell density, nucleus to cytoplasmic ratio, and epithelial cell morphology) were evaluated and compared between eyes before and after treatment (repeated measurement of ANOVA). RESULTS: After treatment, BUT and tear wettings were significantly prolonged in each group. Topical CsA treated eyes had greater increase in BUT (p=0.026); there was no significant difference in tear wetting (p=0.132). While the 3 parameters of CIC improved in both groups, goblet cell density was significantly higher in eyes treated with CsA (p=0.033). CONCLUSIONS: While both CS-HA and 0.05% CsA eyedrops improve ocular surfaces, topical CsA may have a better effect on enhancing tear film stability and goblet cell density.
- 1011-8942 (Print)
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