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Risk factors for and clinical outcomes of carbapenem non-susceptible gram negative bacilli bacteremia in patients with acute myelogenous leukemia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Dong Hoon | - |
dc.contributor.author | Shin, Dong-Yeop | - |
dc.contributor.author | Kang, Chang Kyung | - |
dc.contributor.author | Park, Suhyeon | - |
dc.contributor.author | Park, Jieun | - |
dc.contributor.author | Jun, Kang I | - |
dc.contributor.author | Kim, Taek Soo | - |
dc.contributor.author | Koh, Youngil | - |
dc.contributor.author | Hong, Jun Shik | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Kim, Nam-Joong | - |
dc.contributor.author | Yoon, Sung-soo | - |
dc.contributor.author | Kim, Inho | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.date.accessioned | 2020-07-06T01:53:21Z | - |
dc.date.available | 2020-07-06T01:53:21Z | - |
dc.date.issued | 2020-06-09 | - |
dc.identifier.citation | BMC Infectious Diseases. 2020 Jun 09;20(1):404 | ko_KR |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | https://doi.org/10.1186/s12879-020-05131-2 | - |
dc.identifier.uri | https://hdl.handle.net/10371/168573 | - |
dc.description.abstract | Background
Carbapenem is frequently used when gram negative bacilli (GNB) bacteremia is detected especially in neutropenic patients. Consequently, appropriate treatment could be delayed in GNB bacteremia cases involving organisms which are not susceptible to carbapenem (carba-NS), resulting in a poor clinical outcomes. Here, we explored risk factors for carba-NS GNB bacteremia and its clinical outcomes in patients with acute myelogenous leukemia (AML) that underwent chemotherapy. Methods We reviewed all GNB bacteremia cases that occurred during induction or consolidation chemotherapy, over a 15-year period, in a tertiary-care hospital. Results Among 489 GNB bacteremia cases from 324 patients, 45 (9.2%) were carba-NS and 444 (90.8%) were carbapenem susceptible GNB. Independent risk factors for carba-NS GNB bacteremia were: carbapenem use at bacteremia onset (adjusted odds ratio [aOR]: 91.2; 95% confidence interval [95%CI]: 29.3–284.1; P < 0.001); isolation of carbapenem-resistant Acinetobacter baumannii (aOR: 19.4, 95%CI: 3.4–112.5; P = 0.001) in the prior year; and days from chemotherapy to GNB bacteremia (aOR: 1.1 per day, 95%CI: 1.1–1.2; P < 0.001). Carba-NS bacteremia was independently associated with in-hospital mortality (aOR: 6.6, 95%CI: 3.0–14.8; P < 0.001). Conslusion Carba-NS organisms should be considered for antibiotic selection in AML patients having these risk factors. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Carbapenem non-susceptible | - |
dc.subject | Gram negative bacilli | - |
dc.subject | Bacteremia | - |
dc.subject | Acute myelogenous leukemia | - |
dc.subject | Risk factors | - |
dc.title | Risk factors for and clinical outcomes of carbapenem non-susceptible gram negative bacilli bacteremia in patients with acute myelogenous leukemia | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 신동훈 | - |
dc.contributor.AlternativeAuthor | 신동엽 | - |
dc.contributor.AlternativeAuthor | 강창경 | - |
dc.contributor.AlternativeAuthor | 박수현 | - |
dc.contributor.AlternativeAuthor | 박지은 | - |
dc.contributor.AlternativeAuthor | 전강일 | - |
dc.contributor.AlternativeAuthor | 김택수 | - |
dc.contributor.AlternativeAuthor | 고영일 | - |
dc.contributor.AlternativeAuthor | 홍준식 | - |
dc.contributor.AlternativeAuthor | 최평균 | - |
dc.contributor.AlternativeAuthor | 박완범 | - |
dc.contributor.AlternativeAuthor | 김남중 | - |
dc.contributor.AlternativeAuthor | 윤성수 | - |
dc.contributor.AlternativeAuthor | 김인호 | - |
dc.contributor.AlternativeAuthor | 오명돈 | - |
dc.citation.journaltitle | BMC Infectious Diseases | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2020-06-16T09:29:10Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 404 | ko_KR |
dc.citation.volume | 20 | ko_KR |
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