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Studies on synaptic engram in hippocampus and amygdala using Dual-eGRASP : Dual-eGRASP 기술을 이용한 해마 및 편도에서의 기억 저장 시냅스 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 강봉균 | - |
dc.contributor.author | 최동일 | - |
dc.date.accessioned | 2020-10-13T04:05:25Z | - |
dc.date.available | 2020-10-13T04:05:25Z | - |
dc.date.issued | 2020 | - |
dc.identifier.other | 000000162575 | - |
dc.identifier.uri | https://hdl.handle.net/10371/170765 | - |
dc.identifier.uri | http://dcollection.snu.ac.kr/common/orgView/000000162575 | ko_KR |
dc.description | 학위논문 (박사) -- 서울대학교 대학원 : 자연과학대학 협동과정 뇌과학전공, 2020. 8. 강봉균. | - |
dc.description.abstract | Our daily experiences are stored in the brain as form of memories and define one person's individuality. It has long been human beings interests, where and how the memory is encoded in our brain. In this acquisition and storage process of memories, structural and physiological changes occur, which is considered as the physical substrates of the memory or the engram. During the memory formation, synapses between neurons undergo plasticity. Neurobiologists have tried to observe these changes in the synapses between engram cells. However, substrate at synapse-level within engram cells remains elusive, because of technical limitations. To distinguish the connections between engram cell and other neurons, I developed and applied dual-eGRASP technique.
Using Dual-eGRASP, I could capture the Synaptic engrams in the hippocampus and amygdala, which are the connections between pre- and post-synaptic engram cells among intermingled neuronal ensembles. Tracking the synaptic engram in hippocampus CA3 to CA1 Schaffer-collateral pathway, I found the strength of memory is correlated with density and spine size of synaptic engrams, not depend on number of engram cells. Moreover, in the lateral amygdala (LA), I found that extinction of fear memory reversed the synaptic enhancement induced by fear conditioning. In addition, re-conditioning with same tone and shock recovered the spine size of synaptic engram decreased by fear extinction. These results indicate that the connections between engram cells, synaptic engram, represents the state of memory. These synaptic-level engram approaches will provide information on the question, how the memory is encoded in our brain. | - |
dc.description.tableofcontents | Chapter I. Introduction 7
Background 8 Purpose of this study 15 Chapter II. Identification of synaptic engram using DualeGRASP 17 Introduction 18 Experimental Procedures 20 Results 25 Discussion 36 Chapter III. Strength of memory is correlated with density and spine size of synaptic engram 38 Introduction 39 Experimental Procedures 41 Results 46 Discussion 58 Chapter IV. Synaptic engram represents the state of memory; Conditioning, Extinction, Re-conditioning 59 Introduction 60 Experimental Procedures 62 Results 67 Discussion 79 Chapter V. Conclusion 82 References 85 국문초록 90 | - |
dc.language.iso | eng | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Memory | - |
dc.subject | Engram | - |
dc.subject | Hippocampus | - |
dc.subject | Amygdala | - |
dc.subject | Extinction | - |
dc.subject | Dual-eGRASP | - |
dc.subject | 기억 | - |
dc.subject | 엔그램 | - |
dc.subject | 해마 | - |
dc.subject | 편도 | - |
dc.subject | 기억소거 | - |
dc.subject.ddc | 611.81 | - |
dc.title | Studies on synaptic engram in hippocampus and amygdala using Dual-eGRASP | - |
dc.title.alternative | Dual-eGRASP 기술을 이용한 해마 및 편도에서의 기억 저장 시냅스 연구 | - |
dc.type | Thesis | - |
dc.type | Dissertation | - |
dc.contributor.department | 자연과학대학 협동과정 뇌과학전공 | - |
dc.description.degree | Doctor | - |
dc.date.awarded | 2020-08 | - |
dc.identifier.uci | I804:11032-000000162575 | - |
dc.identifier.holdings | 000000000043▲000000000048▲000000162575▲ | - |
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