Publications
Detailed Information
Cu-Catalyzed Enantioselective 1,4-Addition of 1,1-Bis[(pinacolato)boryl]methane
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이홍근 | - |
dc.contributor.author | 김창희 | - |
dc.date.accessioned | 2020-10-13T04:07:32Z | - |
dc.date.available | 2020-10-13T04:07:32Z | - |
dc.date.issued | 2020 | - |
dc.identifier.other | 000000163267 | - |
dc.identifier.uri | https://hdl.handle.net/10371/170804 | - |
dc.identifier.uri | http://dcollection.snu.ac.kr/common/orgView/000000163267 | ko_KR |
dc.description | 학위논문 (석사) -- 서울대학교 대학원 : 자연과학대학 화학부, 2020. 8. 이홍근. | - |
dc.description.abstract | A Cu-catalyzed enantioselective 1,4-addition of 1,1-bis[(pinacolato)boryl]methane to an α,β-unsaturated carbonyl system has been developed. This enantioselective reaction showed good to moderate yield and % ee on chalcone derivatives and other alkyl-substituted analogues. Moreover, the product, γ-borylated dihydrochalcone, could be employed to various further transformations with modifying its oxidation state. Finally, additive effect was investigated by employing 31P and 11B NMR. | - |
dc.description.abstract | 본문에서는 구리 촉매를 이용한 1,1-비스피나콜라토보릴메테인의 입체 선택적인 1,4-첨가반응을 소개한다. 이 반응은 알파, 베타-불포화 케톤 (찰콘 및 그의 유도체)에 대해 입체선택적으로 보릴-알킬족을 첨가한다. 생성물인 감마-보릴다이하이드로찰콘은 여러 방법으로 작용기를 선택적으로 변화시킬 수 있다. 이 반응을 개발하는 과정에서, 리튬-아세틸아세토네이트의 효과를 31P 및 11B NMR 분석법을 사용하여 밝혀내었다. | - |
dc.description.tableofcontents | 1. Introduction 1
2. Results and Discussion 5 2-1. Evaluations of Reaction Conditions 5 2-2. Substrate Scope 10 2-3. Further Derivatizations 13 2-4. NMR Study on Additive Effect 14 3. Conclusion 18 4. Experimental Section 19 5. References 54 | - |
dc.language.iso | eng | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | α,β-unsaturated carbonyl system | - |
dc.subject | enantioselective | - |
dc.subject | γ-borylated dihydrochalcone | - |
dc.subject | 1,1-bis[(pinacolato)boryl]methane | - |
dc.subject | 알파 | - |
dc.subject | 베타-불포화 케톤 | - |
dc.subject | 입체 선택적 | - |
dc.subject | 감마-보릴다이하이드 로찰콘 | - |
dc.subject | 1,1-비스피나콜라토보릴메테인 | - |
dc.subject.ddc | 540 | - |
dc.title | Cu-Catalyzed Enantioselective 1,4-Addition of 1,1-Bis[(pinacolato)boryl]methane | - |
dc.type | Thesis | - |
dc.type | Dissertation | - |
dc.contributor.department | 자연과학대학 화학부 | - |
dc.description.degree | Master | - |
dc.date.awarded | 2020-08 | - |
dc.contributor.major | 유기화학 | - |
dc.identifier.uci | I804:11032-000000163267 | - |
dc.identifier.holdings | 000000000043▲000000000048▲000000163267▲ | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.