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Cu-Catalyzed Enantioselective 1,4-Addition of 1,1-Bis[(pinacolato)boryl]methane

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dc.contributor.advisor이홍근-
dc.contributor.author김창희-
dc.date.accessioned2020-10-13T04:07:32Z-
dc.date.available2020-10-13T04:07:32Z-
dc.date.issued2020-
dc.identifier.other000000163267-
dc.identifier.urihttps://hdl.handle.net/10371/170804-
dc.identifier.urihttp://dcollection.snu.ac.kr/common/orgView/000000163267ko_KR
dc.description학위논문 (석사) -- 서울대학교 대학원 : 자연과학대학 화학부, 2020. 8. 이홍근.-
dc.description.abstractA Cu-catalyzed enantioselective 1,4-addition of 1,1-bis[(pinacolato)boryl]methane to an α,β-unsaturated carbonyl system has been developed. This enantioselective reaction showed good to moderate yield and % ee on chalcone derivatives and other alkyl-substituted analogues. Moreover, the product, γ-borylated dihydrochalcone, could be employed to various further transformations with modifying its oxidation state. Finally, additive effect was investigated by employing 31P and 11B NMR.-
dc.description.abstract본문에서는 구리 촉매를 이용한 1,1-비스피나콜라토보릴메테인의 입체 선택적인 1,4-첨가반응을 소개한다. 이 반응은 알파, 베타-불포화 케톤 (찰콘 및 그의 유도체)에 대해 입체선택적으로 보릴-알킬족을 첨가한다. 생성물인 감마-보릴다이하이드로찰콘은 여러 방법으로 작용기를 선택적으로 변화시킬 수 있다. 이 반응을 개발하는 과정에서, 리튬-아세틸아세토네이트의 효과를 31P 및 11B NMR 분석법을 사용하여 밝혀내었다.-
dc.description.tableofcontents1. Introduction 1

2. Results and Discussion 5
2-1. Evaluations of Reaction Conditions 5
2-2. Substrate Scope 10
2-3. Further Derivatizations 13
2-4. NMR Study on Additive Effect 14

3. Conclusion 18

4. Experimental Section 19

5. References 54
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dc.language.isoeng-
dc.publisher서울대학교 대학원-
dc.subjectα,β-unsaturated carbonyl system-
dc.subjectenantioselective-
dc.subjectγ-borylated dihydrochalcone-
dc.subject1,1-bis[(pinacolato)boryl]methane-
dc.subject알파-
dc.subject베타-불포화 케톤-
dc.subject입체 선택적-
dc.subject감마-보릴다이하이드 로찰콘-
dc.subject1,1-비스피나콜라토보릴메테인-
dc.subject.ddc540-
dc.titleCu-Catalyzed Enantioselective 1,4-Addition of 1,1-Bis[(pinacolato)boryl]methane-
dc.typeThesis-
dc.typeDissertation-
dc.contributor.department자연과학대학 화학부-
dc.description.degreeMaster-
dc.date.awarded2020-08-
dc.contributor.major유기화학-
dc.identifier.uciI804:11032-000000163267-
dc.identifier.holdings000000000043▲000000000048▲000000163267▲-
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College of Natural Sciences (자연과학대학)Dept. of Chemistry (화학부)Theses (Master's Degree_화학부)
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