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The association of genetic polymorphisms with nonalcoholic fatty liver disease in a longitudinal study

Cited 1 time in Web of Science Cited 1 time in Scopus
Authors
Chung, Goh Eun; Shin, Eunsoon; Kwak, Min-Sun; Yang, Jong In; Lee, Jong-Eun; Choe, Eun Kyung; Yim, Jeong Yoon
Issue Date
2020-10-15
Publisher
BMC
Citation
BMC Gastroenterology. 2020 Oct 15;20(1):344
Keywords
Nonalcoholic fatty liver diseaseGenome-wide association studySingle-nucleotide polymorphism
Abstract
Background
Several genetic variants are known to be associated with nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the longitudinal associations between genetic variants and NAFLD.

Methods
We performed a genome-wide association study (GWAS) in Korean individuals who underwent repeated health check-ups. NAFLD was defined by ultrasonography and exclusion of secondary causes.

Results
The subjects had a median age of 50.0 years, and 54.8% were male. The median follow-up duration was 39 months. Among the 3905 subjects without NAFLD at baseline, 874 (22.4%) subjects developed NAFLD, and among the 1818 subjects with NAFLD at baseline, NAFLD regressed in 336 (18.5%) subjects during the follow-up period. After adjusting for age, sex and body mass index, no single-nucleotide polymorphism (SNP) passed Bonferroni correction for genome-wide significance in the development or regression of NAFLD. Among the SNPs that passed the genome-wide suggestiveness threshold (p = 1E-04) in the discovery set in the GWAS, only 1 SNP (rs4906353) showed an association with the development of NAFLD, with marginal significance in the validation set (p-value, discovery set = 9.68E-5 and validation set = 0.00531).

Conclusions
This exploratory study suggests that longitudinal changes in NAFLD are not associated with genetic variants in the Korean population. These findings provide new insight into genetic mechanisms in the pathogenesis of NAFLD.
ISSN
1471-230X
Language
English
URI
https://hdl.handle.net/10371/171615
DOI
https://doi.org/10.1186/s12876-020-01469-8
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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