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Antiproliferation effect of sulforaphene isolated from radish (Raphanus sativus L.) seeds on A549 cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Sooyeon | - |
dc.contributor.author | Ahn, Jin-Chul | - |
dc.contributor.author | Lee, Eun Jin | - |
dc.contributor.author | Kim, Jongkee | - |
dc.date.accessioned | 2021-01-18T04:44:36Z | - |
dc.date.available | 2021-01-18T13:58:50Z | - |
dc.date.issued | 2020-11-11 | - |
dc.identifier.citation | Applied Biological Chemistry. 2020 Nov 11;63(1):75 | ko_KR |
dc.identifier.issn | 2468-0842 | - |
dc.identifier.uri | https://hdl.handle.net/10371/171652 | - |
dc.description.abstract | Sulforaphene (SFE), a major isothiocyanate in radish seeds, is a close chemical relative of sulforaphane (SFA) isolated from broccoli seeds and florets. The anti-proliferative mechanisms of SFA against cancer cells have been well investigated, but little is known about the potential anti-proliferative effects of SFE. In this study, we showed that SFE purified from radish seeds inhibited the growth of six cancer cell lines (A549, CHO, HeLa, Hepa1c1c7, HT-29, and LnCaP), with relative half maximal inhibitory concentration values ranging from 1.37 to 3.31μg/mL. Among the six cancer cell lines, SFE showed the greatest growth inhibition against A549 lung cancer cells, where it induced apoptosis by changing the levels of poly(ADP-ribose) polymerase and caspase-3, -8, and -9. Our results indicate that SFE from radish seeds may have significant anti-proliferative potency against a broad range of human cancer cells via induction of apoptosis. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Springer Open | ko_KR |
dc.subject | Anti-proliferation | - |
dc.subject | Brassica vegetables | - |
dc.subject | Human disease | - |
dc.subject | Isothiocyanate | - |
dc.subject | MTT assay | - |
dc.title | Antiproliferation effect of sulforaphene isolated from radish (Raphanus sativus L.) seeds on A549 cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 임수연 | - |
dc.contributor.AlternativeAuthor | 안진철 | - |
dc.contributor.AlternativeAuthor | 이은진 | - |
dc.contributor.AlternativeAuthor | 김종기 | - |
dc.identifier.doi | 10.1186/s13765-020-00561-7 | - |
dc.citation.journaltitle | Applied Biological Chemistry | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2020-11-15T04:06:40Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 75 | ko_KR |
dc.citation.volume | 63 | ko_KR |
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