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Antiproliferation effect of sulforaphene isolated from radish (Raphanus sativus L.) seeds on A549 cells

DC Field Value Language
dc.contributor.authorLim, Sooyeon-
dc.contributor.authorAhn, Jin-Chul-
dc.contributor.authorLee, Eun Jin-
dc.contributor.authorKim, Jongkee-
dc.date.accessioned2021-01-18T04:44:36Z-
dc.date.available2021-01-18T13:58:50Z-
dc.date.issued2020-11-11-
dc.identifier.citationApplied Biological Chemistry. 2020 Nov 11;63(1):75ko_KR
dc.identifier.issn2468-0842-
dc.identifier.urihttps://hdl.handle.net/10371/171652-
dc.description.abstractSulforaphene (SFE), a major isothiocyanate in radish seeds, is a close chemical relative of sulforaphane (SFA) isolated from broccoli seeds and florets. The anti-proliferative mechanisms of SFA against cancer cells have been well investigated, but little is known about the potential anti-proliferative effects of SFE. In this study, we showed that SFE purified from radish seeds inhibited the growth of six cancer cell lines (A549, CHO, HeLa, Hepa1c1c7, HT-29, and LnCaP), with relative half maximal inhibitory concentration values ranging from 1.37 to 3.31 μg/mL. Among the six cancer cell lines, SFE showed the greatest growth inhibition against A549 lung cancer cells, where it induced apoptosis by changing the levels of poly(ADP-ribose) polymerase and caspase-3, -8, and -9. Our results indicate that SFE from radish seeds may have significant anti-proliferative potency against a broad range of human cancer cells via induction of apoptosis.ko_KR
dc.language.isoenko_KR
dc.publisherSpringer Openko_KR
dc.subjectAnti-proliferation-
dc.subjectBrassica vegetables-
dc.subjectHuman disease-
dc.subjectIsothiocyanate-
dc.subjectMTT assay-
dc.titleAntiproliferation effect of sulforaphene isolated from radish (Raphanus sativus L.) seeds on A549 cellsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor임수연-
dc.contributor.AlternativeAuthor안진철-
dc.contributor.AlternativeAuthor이은진-
dc.contributor.AlternativeAuthor김종기-
dc.identifier.doi10.1186/s13765-020-00561-7-
dc.citation.journaltitleApplied Biological Chemistryko_KR
dc.language.rfc3066en-
dc.rights.holderThe Author(s)-
dc.date.updated2020-11-15T04:06:40Z-
dc.citation.number1ko_KR
dc.citation.startpage75ko_KR
dc.citation.volume63ko_KR
Appears in Collections:
College of Agriculture and Life Sciences (농업생명과학대학)Research Institute of Agriculture and Life Sciences (농업생명과학연구원)Journal Papers (저널논문_농업생명과학연구원)
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