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Effect of magnesium supplementation on emergence delirium and postoperative pain in children undergoing strabismus surgery: a prospective randomised controlled study

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Authors
Lee, Ji-Hyun; Choi, Seungeun; Lee, Minkyoo; Jang, Young-Eun; Kim, Eun-Hee; Kim, Jin-Tae; Kim, Hee-Soo
Issue Date
2020-11-18
Publisher
BMC
Citation
BMC Anesthesiology. 2020 Nov 18;20(1):289
Keywords
Emergence deliriumMagnesiumOphthalmologic surgical procedurePaediatricsPain
Abstract
Background
The benefits of intraoperative magnesium supplementation have been reported. In this prospective, randomized study, the effects of magnesium supplementation during general anaesthesia on emergence delirium and postoperative pain in children were evaluated.

Methods
A total of 66 children aged 2 to 5 years who underwent strabismus surgery were assigned to the magnesium or to the control group. Preoperative anxiety was assessed using the modified Yale Preoperative Anxiety Scale. After anaesthesia induction, the magnesium group received an initial loading dose of 30 mg/kg magnesium sulphate over 10 min and, then, continuous infusion of 10 mg/kg per h until 10 min before the end of the surgery. The control group received an equal volume of normal saline via the same regimen. The Paediatric Anaesthesia Emergence Delirium (PAED) score, pain score, and respiratory events were assessed at the postanaesthetic care unit.

Results
Data obtained from 65 children were analyzed. The PAED and pain scores of the two groups did not differ significantly. There were 26 of 33 (78.8%) and 27 of 32 (84.4%) children with emergence delirium in the control and the magnesium groups, respectively (odds ratio 0.69, 95% CI 0.19–2.44; p = 0.561). The preoperative anxiety score was not significantly correlated with the PAED score. The incidence of respiratory events during the emergence period did not differ significantly between the two groups.

Conclusions
Magnesium supplementation during anaesthesia had no significant effects on the incidence of emergence delirium or postoperative pain in children undergoing strabismus surgery.

Trial registration
ClinicalTrials.gov (
NCT03132701

). Prospectively registered May 8, 2017.
ISSN
1471-2253
Language
English
URI
https://hdl.handle.net/10371/171691
DOI
https://doi.org/10.1186/s12871-020-01192-7
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College of Medicine/School of Medicine (의과대학/대학원)Anesthesiology and Pain Medicine (마취통증의학전공)Journal Papers (저널논문_마취통증의학전공)
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