S-Space College of Natural Sciences (자연과학대학) Brain and Cognitive Sciences (뇌인지과학과) Journal Papers (저널논문_뇌인지과학과)
Smaller pineal gland is associated with rapid eye movement sleep behavior disorder in Alzheimers disease
Cited 4 time in Web of Science Cited 4 time in Scopus
- Issue Date
- Alzheimer's Research & Therapy. 2020 Nov 21;12(1):157
- Alzheimer’s disease ; Pineal gland ; Rapid eye movement sleep behavior disorder ; Magnetic resonance imaging ; Amyloid positron emission tomography
To investigate the association between pineal gland volume and symptoms of rapid eye movement (REM) sleep behavior disorder (RBD) in Alzheimers disease (AD) patients without any feature of dementia with Lewy bodies.
We enrolled 296 community-dwelling probable AD patients who did not meet the diagnostic criteria for possible or probable dementia with Lewy bodies. Among them, 93 were amyloid beta (Aβ) positive on 18F-florbetaben amyloid brain positron emission tomography. We measured RBD symptoms using the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) and defined probable RBD (pRBD) as the RBDSQ of 5 or higher. We manually segmented pineal gland on 3T structural T1-weighted brain magnetic resonance imaging.
The participants with pRBD had smaller pineal parenchyma volume (VPP) than those without pRBD (p < 0.001). The smaller the VPP, the more severe the RBD symptoms (p < 0.001). VPP was inversely associated with risk of prevalent pRBD (odds ratio = 0.909, 95% confidence interval [CI] = 0.878–0.942, p < 0.001). Area under the receiver operator characteristic curve for pRBD of VPP was 0.80 (95% CI = 0.750–0.844, p < 0.0001). These results were not changed when we analyzed the 93 participants with Aβ-positive AD separately.
In AD patients, reduced pineal gland volume may be associated with RBD.
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