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Adenine base editors catalyze cytosine conversions in human cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Heon Seok | - |
dc.contributor.author | Jeong, You Kyeong | - |
dc.contributor.author | Hur, Junho K. | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.contributor.author | Bae, Sangsu | - |
dc.date.accessioned | 2021-01-31T03:08:30Z | - |
dc.date.available | 2021-01-31T03:08:30Z | - |
dc.date.created | 2020-04-27 | - |
dc.date.created | 2020-04-27 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | Nature Biotechnology, Vol.37 No.10, pp.1145-1148 | - |
dc.identifier.issn | 1087-0156 | - |
dc.identifier.other | 97595 | - |
dc.identifier.uri | https://hdl.handle.net/10371/171743 | - |
dc.description.abstract | Adenine base editors comprise an adenosine deaminase, evolved in vitro, and a Cas9 nickase. Here, we show that in addition to converting adenine to guanine, adenine base editors also convert cytosine to guanine or thymine in a narrow editing window (positions 5-7) and in a confined TC*N sequence context. Adenine base editor-induced cytosine substitutions occur independently of adenosine conversions with an efficiency of up to 11.2% and reduce the number of suitable targeting sites for high-specificity base editing. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Adenine base editors catalyze cytosine conversions in human cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김진수 | - |
dc.identifier.doi | 10.1038/s41587-019-0254-4 | - |
dc.citation.journaltitle | Nature Biotechnology | - |
dc.identifier.wosid | 000493315800015 | - |
dc.identifier.scopusid | 2-s2.0-85072942908 | - |
dc.citation.endpage | 1148 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 1145 | - |
dc.citation.volume | 37 | - |
dc.identifier.sci | 000493315800015 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GENOMIC DNA | - |
dc.subject.keywordPlus | TARGET | - |
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