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Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex
DC Field | Value | Language |
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dc.contributor.author | Kataoka, Naoyuki | - |
dc.contributor.author | Diem, Michael D. | - |
dc.contributor.author | Kim, V. Narry | - |
dc.contributor.author | Yong, Jeongsik | - |
dc.contributor.author | Dreyfuss, Gideon | - |
dc.date.accessioned | 2021-01-31T08:11:34Z | - |
dc.date.available | 2021-01-31T08:11:34Z | - |
dc.date.created | 2020-07-16 | - |
dc.date.issued | 2001-11 | - |
dc.identifier.citation | EMBO Journal, Vol.20 No.22, pp.6424-6433 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.other | 107109 | - |
dc.identifier.uri | https://hdl.handle.net/10371/171884 | - |
dc.description.abstract | The RNA-binding protein Y14 binds preferentially to mRNAs produced by splicing and is a component of a multiprotein complex that assembles similar to 20 nucleotides upstream of exon-exon junctions. This complex probably has important functions in post-splicing events including nuclear export and nonsense-mediated decay of mRNA. We show that Y14 binds to two previously reported components, Aly/REF and RNPS1, and to the mRNA export factor TAP. Moreover, we identified magoh, a human homolog of the Drosophila mago nashi gene product, as a novel component of the complex. Magoh binds avidly and directly to Y14 and TAP, but not to other known components of the complex, and is found in Y14-containing mRNPs in vivo. Importantly, magoh also binds to mRNAs produced by splicing upstream (similar to 20 nucleotides) of exon-exon junctions and its binding to mRNA persists after export. These experiments thus reveal specific protein-protein interactions among the proteins of the splicing-dependent mRNP complex and suggest an important role for the highly evolutionarily conserved magoh protein in this complex. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김빛내리 | - |
dc.identifier.doi | 10.1093/emboj/20.22.6424 | - |
dc.citation.journaltitle | EMBO Journal | - |
dc.identifier.wosid | 000172403000025 | - |
dc.identifier.scopusid | 2-s2.0-0035890258 | - |
dc.citation.endpage | 6433 | - |
dc.citation.number | 22 | - |
dc.citation.startpage | 6424 | - |
dc.citation.volume | 20 | - |
dc.identifier.sci | 000172403000025 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, V. Narry | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NONSENSE-MEDIATED DECAY | - |
dc.subject.keywordPlus | RNA BINDING-PROTEINS | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | NUCLEAR EXPORT | - |
dc.subject.keywordPlus | TRANSLATION TERMINATION | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | SURVEILLANCE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | CYTOPLASM | - |
dc.subject.keywordPlus | PRODUCT | - |
dc.subject.keywordAuthor | exon-exon junction complex | - |
dc.subject.keywordAuthor | magoh | - |
dc.subject.keywordAuthor | mago nashi | - |
dc.subject.keywordAuthor | splicing | - |
dc.subject.keywordAuthor | Y14 | - |
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