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Conserved microRNA miR-8 controls body size in response to steroid signaling in Drosophila

Cited 63 time in Web of Science Cited 66 time in Scopus
Authors
Jin, Hua; Kim, V. Narry; Hyun, Seogang
Issue Date
2012-07
Citation
Genes and Development, Vol.26 No.13, pp.1427-1432
Keywords
body sizeecdysoneinsulin signalingmaturationmir-8ush
Abstract
Body size determination is a process that is tightly linked with developmental maturation. Ecdysone, an insect maturation hormone, contributes to this process by antagonizing insulin signaling and thereby suppressing juvenile growth. Here, we report that the microRNA miR-8 and its target, u-shaped (USH), a conserved microRNA/target axis that regulates insulin signaling, are critical for ecdysone-induced body size determination in Drosophila. We found that the miR-8 level is reduced in response to ecdysone, while the USH level is up-regulated reciprocally, and that miR-8 is transcriptionally repressed by ecdysone's early response genes. Furthermore, modulating the miR-8 level correlatively changes the fly body size; either overexpression or deletion of miR-8 abrogates ecdysone-induced growth control. Consistently, perturbation of USH impedes ecdysone's effect on body growth. Thus, miR-8 acts as a molecular rheostat that tunes organismal growth in response to a developmental maturation signal.
ISSN
0890-9369
URI
https://hdl.handle.net/10371/171901
DOI
https://doi.org/10.1101/gad.192872.112
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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