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Uridylation by TUT4 and TUT7 marks mRNA for degradation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Jaechul | - |
dc.contributor.author | Ha, Minju | - |
dc.contributor.author | Chang, Hyeshik | - |
dc.contributor.author | Kwon, S. Chul | - |
dc.contributor.author | Simanshu, Dhirendra K. | - |
dc.contributor.author | Patel, Dinshaw J. | - |
dc.contributor.author | Kim, V. Narry | - |
dc.date.accessioned | 2021-01-31T08:12:52Z | - |
dc.date.available | 2021-01-31T08:12:52Z | - |
dc.date.created | 2020-07-16 | - |
dc.date.created | 2020-07-16 | - |
dc.date.created | 2020-07-16 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.citation | Cell, Vol.159 No.6, pp.1365-1376 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.other | 107082 | - |
dc.identifier.uri | https://hdl.handle.net/10371/171906 | - |
dc.description.abstract | Uridylation occurs pervasively on mRNAs, yet its mechanism and significance remain unknown. By applying TAIL-seq, we identify TUT4 and TUT7 (TUT4/7), also known as ZCCHC11 and ZCCHC6, respectively, as mRNA uridylation enzymes. Uridylation readily occurs on deadenylated mRNAs in cells. Consistently, purified TUT4/7 selectively recognize and uridylate RNAs with short A-tails (less than similar to 25 nt) in vitro. PABPC1 antagonizes uridylation of polyadenylated mRNAs, contributing to the specificity for short A-tails. In cells depleted of TUT4/7, the vast majority of mRNAs lose the oligo-U-tails, and their half-lives are extended. Suppression of mRNA decay factors leads to the accumulation of oligo-uridylated mRNAs. In line with this, microRNA induces uridylation of its targets, and TUT4/7 are required for enhanced decay of microRNA targets. Our study explains the mechanism underlying selective uridylation of deadenylated mRNAs and demonstrates a fundamental role of oligo-U-tail as a molecular mark for global mRNA decay. | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | Uridylation by TUT4 and TUT7 marks mRNA for degradation | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김빛내리 | - |
dc.identifier.doi | 10.1016/j.cell.2014.10.055 | - |
dc.citation.journaltitle | Cell | - |
dc.identifier.wosid | 000346652900015 | - |
dc.identifier.scopusid | 2-s2.0-84922260726 | - |
dc.citation.endpage | 1376 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 1365 | - |
dc.citation.volume | 159 | - |
dc.identifier.sci | 000346652900015 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lim, Jaechul | - |
dc.contributor.affiliatedAuthor | Kim, V. Narry | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TRANSLATIONAL REPRESSION | - |
dc.subject.keywordPlus | LIN28-LET-7 PATHWAY | - |
dc.subject.keywordPlus | CYTOPLASMIC RNA | - |
dc.subject.keywordPlus | QUALITY-CONTROL | - |
dc.subject.keywordPlus | POLY(A) TAIL | - |
dc.subject.keywordPlus | STEM-LOOP | - |
dc.subject.keywordPlus | 3&apos | - |
dc.subject.keywordPlus | END | - |
dc.subject.keywordPlus | DECAY | - |
dc.subject.keywordPlus | MICRORNA | - |
dc.subject.keywordPlus | PROTEINS | - |
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