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The co-regulation mechanism of transcription factors in the human gene regulatory network
Cited 18 time in
Web of Science
Cited 20 time in Scopus
- Authors
- Issue Date
- 2012-10
- Publisher
- Oxford University Press
- Citation
- Nucleic Acids Research, Vol.40 No.18, pp.8849-8861
- Abstract
- The co-regulation of transcription factors (TFs) has been widely observed in various species. Why is such a co-regulation mechanism needed for transcriptional regulation? To answer this question, the following experiments and analyses were performed. First, examination of the human gene regulatory network (GRN) indicated that co-regulation was significantly enriched in the human GRN. Second, mathematical simulation of an artificial regulatory network showed that the co-regulation mechanism was related to the biphasic dose-response patterns of TFs. Third, the relationship between the co-regulation mechanism and the biphasic dose-response pattern was confirmed using microarray experiments examining different time points and different doses of the toxicant tetrachlorodibenzodioxin. Finally, two mathematical models were constructed to mimic highly co-regulated networks (HCNs) and little co-regulated networks (LCNs), and we found that HCNs were more robust to parameter perturbation than LCNs, whereas LCNs were faster in adaptation to environmental changes than HCNs.
- ISSN
- 0305-1048
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