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Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA

Cited 690 time in Web of Science Cited 726 time in Scopus
Authors
Heo, Inha; Joo, Chirlmin; Cho, Jun; Ha, Minju; Han, Jinju; Kim, V. Narry
Issue Date
2008-10
Citation
Molecular Cell, Vol.32 No.2, pp.276-284
Abstract
The precise control of microRNA (miRNA) biogenesis is critical for embryonic development and normal cellular functions, and its dysregulation is often associated with human diseases. Though the birth and maturation pathway of miRNA has been established, the regulation and death pathway remains largely unknown. Here, we report the RNA-binding proteins, Lin28a and Lin28b, as posttranscriptional repressors of let-7 miRNA biogenesis. We observe that the Lin28 proteins act mainly in the cytoplasm by inducing uridylation of precursor let-7 (pre-let-7) at its 3' end. The uridylated pre-let-7 (up-let-7) fails Dicer processing and undergoes degradation. We provide a mechanism for the posttranscriptional regulation of miRNA biogenesis by Lin28 which is highly expressed in undifferentiated cells and certain cancer cells. The Lin28-mediated downregulation of let-7 may play a key role in development, stem cell programming, and tumorigenesis.
ISSN
1097-2765
URI
https://hdl.handle.net/10371/171933
DOI
https://doi.org/10.1016/j.molcel.2008.09.014
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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