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Human cytomegalovirus microRNA miR-US4-1 inhibits CD8 + T cell responses by targeting the aminopeptidase ERAP1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sungchul | - |
dc.contributor.author | Lee, Sanghyun | - |
dc.contributor.author | Shin, Jinwook | - |
dc.contributor.author | Kim, Youngkyun | - |
dc.contributor.author | Evnouchidou, Irini | - |
dc.contributor.author | Kim, Donghyun | - |
dc.contributor.author | Kim, Young-Kook | - |
dc.contributor.author | Kim, Young-Eui | - |
dc.contributor.author | Ahn, Jin-Hyun | - |
dc.contributor.author | Riddell, Stanley R. | - |
dc.contributor.author | Stratikos, Efstratios | - |
dc.contributor.author | Kim, V. Narry | - |
dc.contributor.author | Ahn, Kwangseog | - |
dc.date.accessioned | 2021-01-31T08:14:36Z | - |
dc.date.available | 2021-01-31T08:14:36Z | - |
dc.date.created | 2020-07-16 | - |
dc.date.issued | 2011-10 | - |
dc.identifier.citation | Nature Immunology, Vol.12 No.10, pp.984-991 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.other | 107033 | - |
dc.identifier.uri | https://hdl.handle.net/10371/171935 | - |
dc.description.abstract | Major histocompatibility complex (MHC) class I molecules present peptides on the cell surface to CD8(+) T cells, which is critical for the killing of virus-infected or transformed cells. Precursors of MHC class I-presented peptides are trimmed to mature epitopes by the aminopeptidase ERAP1. The US2-US11 genomic region of human cytomegalovirus (HCMV) is dispensable for viral replication and encodes three microRNAs (miRNAs). We show here that HCMV miR-US4-1 specifically downregulated ERAP1 expression during viral infection. Accordingly, the trimming of HCMV-derived peptides was inhibited, which led to less susceptibility of infected cells to HCMV-specific cytotoxic T lymphocytes (CTLs). Our findings identify a previously unknown viral miRNA-based CTL-evasion mechanism that targets a key step in the MHC class I antigen-processing pathway. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Human cytomegalovirus microRNA miR-US4-1 inhibits CD8 + T cell responses by targeting the aminopeptidase ERAP1 | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김빛내리 | - |
dc.identifier.doi | 10.1038/ni.2097 | - |
dc.citation.journaltitle | Nature Immunology | - |
dc.identifier.wosid | 000295084500014 | - |
dc.identifier.scopusid | 2-s2.0-80052966924 | - |
dc.citation.endpage | 991 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 984 | - |
dc.citation.volume | 12 | - |
dc.identifier.sci | 000295084500014 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, V. Narry | - |
dc.contributor.affiliatedAuthor | Ahn, Kwangseog | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CLASS-I MOLECULES | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | PRESENTED PEPTIDES | - |
dc.subject.keywordPlus | ENCODED MICRORNAS | - |
dc.subject.keywordPlus | TRIMS PRECURSORS | - |
dc.subject.keywordPlus | BINDING-SITES | - |
dc.subject.keywordPlus | HEAVY-CHAINS | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
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