Browse

Biogenesis of small RNAs in animals

Cited 2238 time in Web of Science Cited 2347 time in Scopus
Authors
Kim, V. Narry; Han, Jinju; Siomi, Mikiko C.
Issue Date
2009-02
Citation
Nature Reviews Molecular Cell Biology, Vol.10 No.2, pp.126-139
Abstract
Small RNAs of 20-30 nucleotides can target both chromatin and transcripts, and thereby keep both the genome and the transcriptome under extensive surveillance. Recent progress in high-throughput sequencing has uncovered an astounding landscape of small RNAs in eukaryotic cells. Various small RNAs of distinctive characteristics have been found and can be classified into three classes based on their biogenesis mechanism and the type of Argonaute protein that they are associated with: microRNAs (miRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs) and Piwi-interacting RNAs (piRNAs). This Review summarizes our current knowledge of how these intriguing molecules are generated in animal cells.
ISSN
1471-0072
URI
https://hdl.handle.net/10371/171939
DOI
https://doi.org/10.1038/nrm2632
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse