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miR-29 miRNAs activate p53 by targeting p85α and CDC42

Cited 482 time in Web of Science Cited 505 time in Scopus
Authors
Park, Seong-Yeon; Lee, Jung Hyun; Ha, Minju; Nam, Jin-Wu; Kim, V. Narry
Issue Date
2009-01
Citation
Nature Structural and Molecular Biology, Vol.16 No.1, pp.23-29
Abstract
The tumor suppressor p53 is central to many cellular stress responses. Although numerous protein factors that control p53 have been identified, the role of microRNAs (miRNAs) in regulating p53 remains unexplored. In a screen for miRNAs that modulate p53 activity, we find that miR-29 family members (miR-29a, miR-29b and miR-29c) upregulate p53 levels and induce apoptosis in a p53-dependent manner. We further find that miR-29 family members directly suppress p85a (the regulatory subunit of PI3 kinase) and CDC42 (a Rho family GTPase), both of which negatively regulate p53. Our findings provide new insights into the role of miRNAs in the p53 pathway.
ISSN
1545-9993
URI
https://hdl.handle.net/10371/171947
DOI
https://doi.org/10.1038/nsmb.1533
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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