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MicroRNA precursors in motion: exportin-5 mediates their nuclear export

Cited 176 time in Web of Science Cited 189 time in Scopus
Authors
Kim, V. Narry
Issue Date
2004-04
Citation
Trends in Cell Biology, Vol.14 No.4, pp.156-159
Abstract
The discovery of microRNAs (miRNAs) has changed the paradigm of gene regulation, leaving us with numerous exciting questions regarding what these molecules do and how they originate. A model for miRNA biogenesis has emerged recently, yet several key factors - including the identity of the miRNA nuclear export receptor remained unknown. However, recent studies have shown that exportin-5 (Exp5), a Ran-dependent importin-p-related transport receptor, mediates nuclear export of miRNA precursors (pre-miRNAs).
ISSN
0962-8924
URI
https://hdl.handle.net/10371/171959
DOI
https://doi.org/10.1016/j.tcb.2004.02.006
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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