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Regulation of poly(A) tail and translation during the somatic cell cycle
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jong-Eun | - |
dc.contributor.author | Yi, Hyerim | - |
dc.contributor.author | Kim, Yoosik | - |
dc.contributor.author | Chang, Hyeshik | - |
dc.contributor.author | Kim, V. Narry | - |
dc.date.accessioned | 2021-01-31T08:15:57Z | - |
dc.date.available | 2021-01-31T08:15:57Z | - |
dc.date.created | 2018-08-29 | - |
dc.date.created | 2018-08-29 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | Molecular Cell, Vol.62 No.3, pp.462-471 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.other | 48351 | - |
dc.identifier.uri | https://hdl.handle.net/10371/171960 | - |
dc.description.abstract | Poly(A) tails are critical for mRNA stability and translation. However, recent studies have challenged this view, showing that poly(A) tail length and translation efficiency are decoupled in non-embryonic cells. Using TAIL-seq and ribosome profiling, we investigate poly(A) tail dynamics and translational control in the somatic cell cycle. We find dramatic changes in poly(A) tail lengths of cell-cycle regulatory genes like CDK1, TOP2A, and FBXO5, explaining their translational repression in M phase. We also find that poly(A) tail length is coupled to translation when the poly(A) tail is <20 nucleotides. However, as most genes have >20 nucleotide poly(A) tails, their translation is regulated mainly via poly(A) tail length-independent mechanisms during the cell cycle. Specifically, we find that terminal oligopyrimidine (TOP) tract-containing transcripts escape global translational suppression in M phase and are actively translated. Our quantitative and comprehensive data provide a revised view of translational control in the somatic cell cycle. | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | Regulation of poly(A) tail and translation during the somatic cell cycle | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김빛내리 | - |
dc.identifier.doi | 10.1016/j.molcel.2016.04.007 | - |
dc.citation.journaltitle | Molecular Cell | - |
dc.identifier.wosid | 000376444700015 | - |
dc.identifier.scopusid | 2-s2.0-84966657920 | - |
dc.citation.endpage | 471 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 462 | - |
dc.citation.volume | 62 | - |
dc.identifier.sci | 000376444700015 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, V. Narry | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MESSENGER-RNA TRANSLATION | - |
dc.subject.keywordPlus | RIBOSOME ENTRY SITE | - |
dc.subject.keywordPlus | PROTEIN-SYNTHESIS | - |
dc.subject.keywordPlus | INCREASED PHOSPHORYLATION | - |
dc.subject.keywordPlus | DEPENDENT TRANSLATION | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | DECREASED RATE | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | MITOSIS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
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