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Two splice variants of the IDD14 transcription factor competitively form nonfunctional heterodimers which may regulate starch metabolism
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Pil Joon | - |
dc.contributor.author | Kim, Mi Jung | - |
dc.contributor.author | Ryu, Jae-Yong | - |
dc.contributor.author | Jeong, Eun-Young | - |
dc.contributor.author | Park, Chung-Mo | - |
dc.date.accessioned | 2021-01-31T08:20:28Z | - |
dc.date.available | 2021-01-31T08:20:28Z | - |
dc.date.created | 2018-01-10 | - |
dc.date.issued | 2011-05 | - |
dc.identifier.citation | Nature Communications, Vol.2 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.other | 14035 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172019 | - |
dc.description.abstract | Alternative splicing of primary gene transcripts provides eukaryotic cells, with a critical scheme for enriching transcriptome and proteome diversity. Here we report that alternative splicing of the Arabidopsis INDERMINATE DOMAIN 14 (IDD14) transcription factor gene generates a competitive inhibitor in regulating starch metabolism. An alternatively spliced IDD14 form (IDD14 beta), which is produced predominantly under cold conditions, lacks functional DNA-binding domain but is able to form heterodimers with the functional IDD14 form (IDD14 alpha). IDD14 alpha-IDD14 beta heterodimers have reduced binding activity to the promoter of Qua-Quine Starch (QQS) gene that regulates starch accumulation. Transgenic Arabidopsis plants overproducing IDD14 alpha (35S:IDD14 alpha) exhibited retarded growth with pale green leaves as appeared on QQS-overexpressing plants. Notably, IDD14 beta overproduction rescued the 35S:IDD14 alpha phenotypes. We propose that alternative splicing of the IDD14 gene generates a self-controlled regulatory loop that may modulate starch accumulation in response to cold. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Two splice variants of the IDD14 transcription factor competitively form nonfunctional heterodimers which may regulate starch metabolism | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 박충모 | - |
dc.identifier.doi | 10.1038/ncomms1303 | - |
dc.citation.journaltitle | Nature Communications | - |
dc.identifier.wosid | 000294802600008 | - |
dc.identifier.scopusid | 2-s2.0-79955887707 | - |
dc.citation.volume | 2 | - |
dc.identifier.sci | 000294802600008 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Seo, Pil Joon | - |
dc.contributor.affiliatedAuthor | Park, Chung-Mo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ARABIDOPSIS-THALIANA | - |
dc.subject.keywordPlus | FREEZING TOLERANCE | - |
dc.subject.keywordPlus | RT-PCR | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MALTOSE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordPlus | PLANTS | - |
dc.subject.keywordPlus | GENES | - |
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