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The Arabidopsis NAC transcription factor NTL4 participates in a positive feedback loop that induces programmed cell death under heat stress conditions

Cited 36 time in Web of Science Cited 39 time in Scopus
Authors
Lee, Sangmin; Lee, Hyo-Jun; Huh, Sung Un; Paek, Kyung-Hee; Ha, Jun-Ho; Park, Chung-Mo
Issue Date
2014-10
Citation
Plant Science, Vol.227, pp.76-83
Keywords
Abscisic acid (ABA)ArabidopsisH2O2Heat stressMembrane-bound transcription factor (MTF)Programmed cell death (PCD)
Abstract
Programmed cell death (PCD) is an integral component of plant development and adaptation under adverse environmental conditions. Reactive oxygen species (ROS) are one of the most important players that trigger PCD in plants, and ROS-generating machinery is activated in plant cells undergoing PCD. The membrane-bound NAC transcription factor NTL4 has recently been proven to facilitate ROS production in response to drought stress in Arabidopsis. In this work, we show that NTL4 participates in a positive feedback loop that bursts ROS accumulation to modulate PCD under heat stress conditions. Heat stress induces NTL4 gene transcription and NTL4 protein processing. The level of hydrogen peroxide (H2O2) was elevated in 35S:4 Delta C transgenic plants that overexpress a transcriptionally active nuclear NTL4 form but significantly reduced in NTL4-deficient ntl4 mutants under heat stress conditions. In addition, heat stress-induced cell death was accelerated in the 35S:4 Delta C transgenic plants but decreased in the ntl4 mutants. Notably, H2O2 triggers NTL4 gene transcription and NTL4 protein processing under heat stress conditions. On the basis of these findings, we conclude that NTL4 modulates PCD through a ROS-mediated positive feedback control under heat stress conditions, possibly providing an adaptation strategy by which plants ensure their survival under extreme heat stress conditions. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
ISSN
0168-9452
URI
https://hdl.handle.net/10371/172061
DOI
https://doi.org/10.1016/j.plantsci.2014.07.003
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College of Natural Sciences (자연과학대학)Dept. of Chemistry (화학부)Journal Papers (저널논문_화학부)
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