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3D graphene-cellulose nanofiber hybrid scaffolds for cortical reconstruction in brain injuries
DC Field | Value | Language |
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dc.contributor.author | Hwang, Do Won | - |
dc.contributor.author | Park, Jong Bo | - |
dc.contributor.author | Sung, Dongchul | - |
dc.contributor.author | Park, Subeom | - |
dc.contributor.author | Min, Kyung-Ah | - |
dc.contributor.author | Kim, Kyu Wan | - |
dc.contributor.author | Choi, Yoori | - |
dc.contributor.author | Kim, Han Young | - |
dc.contributor.author | Lee, Eunji | - |
dc.contributor.author | Kim, Han Soo | - |
dc.contributor.author | Jin, Mo Ses | - |
dc.contributor.author | Park, Minsung | - |
dc.contributor.author | Song, Yoo Sung | - |
dc.contributor.author | Park, Jinwoo | - |
dc.contributor.author | Hyun, Jinho | - |
dc.contributor.author | Hong, Suklyun | - |
dc.contributor.author | Cho, Sung-Pyo | - |
dc.contributor.author | Hong, Byung Hee | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.date.accessioned | 2021-01-31T08:26:13Z | - |
dc.date.available | 2021-01-31T08:26:13Z | - |
dc.date.created | 2019-11-29 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | 2D Materials, Vol.6 No.4, p. 045043 | - |
dc.identifier.issn | 2053-1583 | - |
dc.identifier.other | 87293 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172113 | - |
dc.description.abstract | Designing the nature-driven 3D scaffold is essential for reconstructing of the injured brain in association with stem cell replacement therapy. In this paper, we developed brain cortex-mimetic 3D hybrid scaffolds and applied them to a motor-cortectomy rat model. Graphene oxide bacterial cellulose (GO-BC) hybrid scaffold integrated GOs stably and homogeneously within BC nanofibrous building blocks made of BC and amphiphilic comb-like polymers (APCLP). Density functional theory calculations and molecular dynamics simulations revealed higher binding energies between GO-BC and APCLP than between GO or APLCP with BC. The monodispersed human neural stem cells (F3 cells) incorporated within the GO-BC scaffold generated a large number of differentiated neurons with robust neurite outgrowths and possible synapse formation in vitro. In corticectomized rats and nude mice, highly sensitive photoacoustic signals visualized the GO-BC at the implant site. Moreover, the implanted F3 cells within GO-BC were found to survive/proliferate and differentiate to neuronal lineage from the showing neuronal and synapse markers shown on ex vivo immunofluorescence staining in bioluminescence imaging. Cortex-mimetic and stem cell-instructive monodisperse GO-BC hybrid scaffolds are likely to be appropriate nanoplatforms for stem cell implantation to reconstruct injured/lost brain tissues and actively differentiate neural stem cells. | - |
dc.language | 영어 | - |
dc.publisher | Institute of Physics Publishing (IOP) | - |
dc.title | 3D graphene-cellulose nanofiber hybrid scaffolds for cortical reconstruction in brain injuries | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 홍병희 | - |
dc.identifier.doi | 10.1088/2053-1583/ab3889 | - |
dc.citation.journaltitle | 2D Materials | - |
dc.identifier.wosid | 000484763300002 | - |
dc.identifier.scopusid | 2-s2.0-85081660830 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 045043 | - |
dc.citation.volume | 6 | - |
dc.identifier.sci | 000484763300002 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hyun, Jinho | - |
dc.contributor.affiliatedAuthor | Hong, Byung Hee | - |
dc.contributor.affiliatedAuthor | Lee, Dong Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NEURAL STEM-CELLS | - |
dc.subject.keywordPlus | TOTAL-ENERGY CALCULATIONS | - |
dc.subject.keywordPlus | OSTEOGENIC DIFFERENTIATION | - |
dc.subject.keywordPlus | BLOOD-VESSELS | - |
dc.subject.keywordPlus | PLATFORM | - |
dc.subject.keywordPlus | CULTURE | - |
dc.subject.keywordAuthor | graphene oxide | - |
dc.subject.keywordAuthor | bacterial cellulose | - |
dc.subject.keywordAuthor | cortex-mimetic 3D hybrid scaffold | - |
dc.subject.keywordAuthor | corticectomized rat | - |
dc.subject.keywordAuthor | photoacoustic | - |
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