Detailed Information

pH-Triggered Silk Fibroin/Alginate Structures Fabricated in Aqueous Two-Phase System

Cited 5 time in Web of Science Cited 5 time in Scopus

Park, DoYeun; Cheng, Jie; Park, Jong Bo; Shin, Sungchul; Lee, Sang-Hoon; Hong, Byung Hee; Kim, Soo Hyun; Hyun, Jinho; Yang, Chaoyong

Issue Date
American Chemical Society
ACS Biomaterial Science and Engineering, Vol.5 No.11, pp.5897-5905
An aqueous two-phase system (ATPS) is a water-in-water biphasic system, which is generally formed by two incompatible polymers. Recently, considerable effort has been dedicated to search for new ATPS polymer pairs to further expand ATPS's applications. In this paper, a new ATPS system based on silk fibroin (SF) and alginate is introduced. A phase diagram was established to show the critical concentrations for the formation of an SF/alginate ATPS. The present system is sensitive to pH stimulus and transformed from an ATPS into a single-phasic system as pH increases above similar to 9.5. Circular dichroism, fluorescence emission spectra, hydrodynamic diameter, and zeta-potential data together indicate that the SF chains undergo a dramatic extension as pH is increased, which is the reason underlying the pH-triggered phase transition. As feasible applications of this biphasic system, compartmentalized multiplex immunoassay, controlled encapsulation and release, and hierarchical fiber fabrication were demonstrated using the SF/alginate ATPS.
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

  • College of Natural Sciences
  • Department of Chemistry
Research Area Nanofabrication and characterization, Nanomaterials Synthesis, Quantum mechanics and molecular dynamics simulation, 나노재료 합성, 나노제조 및 특성화, 양자역학 및 분자역학 시뮬레이션


Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.