Graphene quantum dots as anti-inflammatory therapy for colitis
- Lee, Byung-Chul; Lee, Jin Young; Kim, Juhee; Yoo, Je Min; Kang, Insung; Kim, Jae-Jun; Shin, Nari; Kim, Dong Jin; Choi, Soon Won; Kim, Donghoon; Hong, Byung Hee; Kang, Kyung-Sun
- Issue Date
- Science advances, Vol.6 No.18, p. eaaz2630
- While graphene and its derivatives have been suggested as a potential nanomedicine in several biomimetic models, their specific roles in immunological disorders still remain elusive. Graphene quantum dots (GQDs) may be suitable for treating intestinal bowel diseases (IBDs) because of their low toxicity in vivo and ease of clearance. Here, GQDs are intraperitoneally injected to dextran sulfate sodium (DSS)-induced chronic and acute colitis model, and its efficacy has been confirmed. In particular, GQDs effectively prevent tissue degeneration and ameliorate intestinal inflammation by inhibiting T(H)1/T(H)17 polarization. Moreover, GQDs switch the polarization of macrophages from classically activated M1 to M2 and enhance intestinal infiltration of regulatory T cells (T-regs). Therefore, GQDs effectively attenuate excessive inflammation by regulating immune cells, indicating that they can be used as promising alternative therapeutic agents for the treatment of autoimmune disorders, including IBDs.