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Graphene quantum dots as anti-inflammatory therapy for colitis

Cited 8 time in Web of Science Cited 9 time in Scopus
Authors
Lee, Byung-Chul; Lee, Jin Young; Kim, Juhee; Yoo, Je Min; Kang, Insung; Kim, Jae-Jun; Shin, Nari; Kim, Dong Jin; Choi, Soon Won; Kim, Donghoon; Hong, Byung Hee; Kang, Kyung-Sun
Issue Date
2020-04
Citation
Science advances, Vol.6 No.18, p. eaaz2630
Abstract
While graphene and its derivatives have been suggested as a potential nanomedicine in several biomimetic models, their specific roles in immunological disorders still remain elusive. Graphene quantum dots (GQDs) may be suitable for treating intestinal bowel diseases (IBDs) because of their low toxicity in vivo and ease of clearance. Here, GQDs are intraperitoneally injected to dextran sulfate sodium (DSS)-induced chronic and acute colitis model, and its efficacy has been confirmed. In particular, GQDs effectively prevent tissue degeneration and ameliorate intestinal inflammation by inhibiting T(H)1/T(H)17 polarization. Moreover, GQDs switch the polarization of macrophages from classically activated M1 to M2 and enhance intestinal infiltration of regulatory T cells (T-regs). Therefore, GQDs effectively attenuate excessive inflammation by regulating immune cells, indicating that they can be used as promising alternative therapeutic agents for the treatment of autoimmune disorders, including IBDs.
ISSN
2375-2548
URI
https://hdl.handle.net/10371/172273
DOI
https://doi.org/10.1126/sciadv.aaz2630
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College of Natural Sciences (자연과학대학)Dept. of Chemistry (화학부)Journal Papers (저널논문_화학부)
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