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Repeated Aerosol Delivery of Carboxyl-terminal Modulator Protein Suppresses Tumor in the Lungs of K-ras(LA1) Mice
DC Field | Value | Language |
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dc.contributor.author | Hwang, Soon-Kyung | - |
dc.contributor.author | Lim, Hwang-Tae | - |
dc.contributor.author | Minai-Tehrani, Arash | - |
dc.contributor.author | Lee, Eun-Sun | - |
dc.contributor.author | Park, Jongmin | - |
dc.contributor.author | Park, Seung Bum | - |
dc.contributor.author | Beck, George R., Jr. | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:37:20Z | - |
dc.date.available | 2021-01-31T08:37:20Z | - |
dc.date.created | 2020-12-15 | - |
dc.date.issued | 2009-06 | - |
dc.identifier.citation | American Journal of Respiratory and Critical Care Medicine, Vol.179 No.12, pp.1131-1140 | - |
dc.identifier.issn | 1073-449X | - |
dc.identifier.other | 119194 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172293 | - |
dc.description.abstract | Rationale: Difficulties in achieving long-term survival of patients with lung cancer treated with conventional therapies suggest that novel approaches are required. Recent advances in aerosol-mediated gene delivery have provided the possibility of an alternative for the safe and effective treatment of lung cancer. Objectives: To investigate the repeated effect of carboxyl-terminal modulator protein (CTMP) on multistage lung tumorigenesis. In this study, we addressed this question by studying the effects of lentivirus-based CTMP in the lungs of 9- and 13-week-old K-ras(LA1) mice, a model of lung cancer. Methods: An aerosol of lentivirus-based CTMP was delivered into 9- and 13-week-old K-ras(LA1) mice, a model of lung cancer, through a nose-only inhalation system twice a week for 4 weeks. The effects of CTMP on lung cancer progression and Akt-related signals were evaluated. Measurements and Main Results: Long-term repeated delivery of CTMP effectively reduced tumor progression in the lungs at different stages of development. Lentiviral-CTMP inhibited protein synthesis and cell cycle and altered Akt signaling pathway in the lungs of 9-week-old K-ras(LA1) mice, and increased apoptosis was observed in the lungs of 13-week-old K-ras(LA1) mice. Conclusions: Long-term repeated viral delivery of CTMP may provide a useful tool for designing lung tumor treatment. | - |
dc.language | 영어 | - |
dc.publisher | American Thoracic Society | - |
dc.title | Repeated Aerosol Delivery of Carboxyl-terminal Modulator Protein Suppresses Tumor in the Lungs of K-ras(LA1) Mice | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1164/rccm.200810-1553OC | - |
dc.citation.journaltitle | American Journal of Respiratory and Critical Care Medicine | - |
dc.identifier.wosid | 000266787500012 | - |
dc.identifier.scopusid | 2-s2.0-67449090626 | - |
dc.citation.endpage | 1140 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | 1131 | - |
dc.citation.volume | 179 | - |
dc.identifier.sci | 000266787500012 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Seung Bum | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | CYSTIC-FIBROSIS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | VECTORS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | CYCLE | - |
dc.subject.keywordPlus | AKT | - |
dc.subject.keywordAuthor | lentivirus | - |
dc.subject.keywordAuthor | carboxyl-terminal modulator protein | - |
dc.subject.keywordAuthor | lung cancer | - |
dc.subject.keywordAuthor | K-ras(LA1) mice | - |
dc.subject.keywordAuthor | aerosol gene delivery | - |
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