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Potential Tumor-tropic Effect of Genetically Engineered Stem Cells Expressing Suicide Enzymes to Selectively Target Invasive Cancer in Animal Models

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Authors
Kim, Seung U.; Jeung, Eui-Bae; Kim, Yun-Bae; Cho, Myung-Haing; Choi, Kyung-Chul
Issue Date
2011-04
Citation
Anticancer Research, Vol.31 No.4, pp.1249-1258
Keywords
Neural stem cellssuicide genesprodrugsinvasive tumorsanimal modelsgene-directed enzyme prodrug therapy review
Abstract
Stem cells have recently received a great deal of attention for their clinical and therapeutic potential to treat human disease and disorders. For instance, neural stein cells expressing a suicide gene which can concert prodrugs to their active metabolites may have great tropic and therapeutic potential for brain tumors, i.e., medulloblastoma and glioma. We are currently interested in therapeutic potential of these genetically engineered stem cells (GESTECs) to selectively target invasive tumors, i.e. ovarian, endometrial, breast, and lung cancer which can have a great impact on human and animal health. Thus, in this review we summarize the therapeutic potential of GESTEC, developed by us, and the putative mechanism(s) underlying their therapeutic and tropic potential in expressing suicide genes which can convert prodrugs to their active metabolites and in selectively targeting invasive tumors.
ISSN
0250-7005
URI
https://hdl.handle.net/10371/172297
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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