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Knockdown of Importin 7 Inhibits Lung Tumorigenesis in K-ras(LA1) Lung Cancer Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ah Young | - |
dc.contributor.author | Kim, Sang Wha | - |
dc.contributor.author | Lee, Somin | - |
dc.contributor.author | Jiang, Hu-Lin | - |
dc.contributor.author | Kim, Sang-Bum | - |
dc.contributor.author | Hong, Seong-Ho | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:37:43Z | - |
dc.date.available | 2021-01-31T08:37:43Z | - |
dc.date.created | 2018-08-31 | - |
dc.date.issued | 2017-05 | - |
dc.identifier.citation | Anticancer Research, Vol.37 No.5, pp.2381-2386 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.other | 49189 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172298 | - |
dc.description.abstract | Background/Aim: Lung cancer shows the highest estimated deaths in both males and females in the Unites States. Importin 7 is overexpressed in lung adenocarcinoma tissues. In this study, we aimed to demonstrate the anticancer effect of importin 7 down-regulation, especially in lung cancer. Materials and Methods: Glycerol propoxylate triacrylate spermine (GPT-SPE) is a biocompatible carrier used for aerosol gene delivery. Repeated aerosol delivery of GPT-SPE/shImportin 7 complexes was performed to 10-week-old male K-ras(LA1) mice (a murine lung cancer model) twice a week for 4 weeks (8 times) in a nose-only exposure chamber. Results: Aerosol delivery of GPT-SPE/shImportin 7 inhibits lung cancer in K-ras(LA1) mice compared to control and scramble control groups. Moreover, importin 7-down-regulated stable cell-line demonstrates suppression of proliferation through Akt inhibition and apoptosis. Conclusion: Down-regulation of importin 7 significantly suppresses lung cancer in vitro and in vivo. | - |
dc.language | 영어 | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.title | Knockdown of Importin 7 Inhibits Lung Tumorigenesis in K-ras(LA1) Lung Cancer Mice | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.21873/anticanres.11576 | - |
dc.citation.journaltitle | Anticancer Research | - |
dc.identifier.wosid | 000402173300026 | - |
dc.identifier.scopusid | 2-s2.0-85019127927 | - |
dc.citation.endpage | 2386 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 2381 | - |
dc.citation.volume | 37 | - |
dc.identifier.sci | 000402173300026 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NUCLEAR TRANSLOCATION | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | AEROSOL DELIVERY | - |
dc.subject.keywordPlus | GENE-THERAPY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | C-MYC | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | SIGNAL | - |
dc.subject.keywordPlus | H1 | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordAuthor | Lung cancer | - |
dc.subject.keywordAuthor | aerosol delivery | - |
dc.subject.keywordAuthor | gene therapy | - |
dc.subject.keywordAuthor | importin 7 | - |
dc.subject.keywordAuthor | GPT-SPE | - |
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