S-Space College of Veterinary Medicine (수의과대학) Dept. of Veterinary Medicine (수의학과) Journal Papers (저널논문_수의학과)
Glucosylated polyethylenimine as a tumor-targeting gene carrier
- Park, In-Kyu; Cook, Seung-Eun; Kim, You -Kyoung; Kim, Hyun -Woo; Cho, Myung -Haing; Jeong, Hwan -Jeong; Kim, Eun -Mi; Nah, Jae -Woon; Bom, Hee -Seung; Cho, Chong -Su
- Issue Date
- Archives of Pharmacal Research, Vol.28 No.11, pp.1302-1310
- Glucosylated polyethylenimine (GPEI) was synthesized as a tumor-targeting gene carrier through facilitative glucose metabolism by tumor glucose transporter. Particle sizes of GPEI/ DNA complex increased in proportion to glucose content of GPEI, whereas surface charge of the complex was not dependent on glucosylation, partially due to inefficient shielding of the short hydrophilic group introduced. GPEI with higher glucosylation (36 mol-%) had no cytotoxic effect on cells even at polymer concentrations higher than 200 mu g/mL. Compared to unglucosylated PEI, glucosylation induced less than one-order decrease of transfection efficiency. Transfection of GPEI/DNA complex into tumor cells possibly occurred through specific interaction between glucose-related cell receptors and glucose moiety of GPEL Gamma imaging technique revealed GPEI/DNA complex was distributed in liver, spleen, and tumors.
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