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Galactosylated chitosan-g-PEI/DNA complexes-loaded poly(organophosphazene) hydrogel as a hepatocyte targeting gene delivery system

Cited 22 time in Web of Science Cited 26 time in Scopus
Authors
Jiang, Hu-Lin; Kim, You-Kyoung; Lee, Sun-Mi; Park, Mi-Ran; Kim, Eun-Mi; Jin, Yong-Mei; Arote, Rohidas; Jeong, Hwan-Jeong; Song, Soo-Chang; Cho, Myung-Haing; Cho, Chong-Su
Issue Date
2010-04
Citation
Archives of Pharmacal Research, Vol.33 No.4, pp.551-556
Keywords
Gene therapyGalactosylated chitosan-g-polyethyleniminePoly(organophosphazene) hydrogelHepatocyte targetingCytotoxicityTransfection efficiency
Abstract
Hydrogels are widely used in drug delivery systems because they can control the release and thereby enhance the efficiency of locally delivered bioactive molecules such as therapeutic drugs, proteins, or genes. For gene delivery, localized release of plasmid DNA or polymer/DNA complexes can transfect cells and produce sustained protein production. We tested the galactosylated chitosan-graft-polyethylenimine (GC-g-PEI)/DNA complexes-loaded poly(organophosphazene) thermosensitive biodegradable hydrogel as a hepatocyte targeting gene delivery system. The poly(organophosphazene) hydrogel loaded with GC-g-PEI/DNA complexes showed low cytotoxicity and higher transfection efficiency than PEI/DNA complexes, as well as good hepatocyte specificity in vitro and in vivo. Our results indicate that poly(organophosphazene) hydrogels loaded with GC-g-PEI/DNA complexes may be a safe and efficient hepatocyte targeting gene delivery system.
ISSN
0253-6269
URI
https://hdl.handle.net/10371/172304
DOI
https://doi.org/10.1007/s12272-010-0409-9
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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