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Magnetite- and maghemite-induced different toxicity in murine alveolar macrophage cells
DC Field | Value | Language |
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dc.contributor.author | Park, Eun-Jung | - |
dc.contributor.author | Umh, Ha Nee | - |
dc.contributor.author | Choi, Dong-Hyuk | - |
dc.contributor.author | Cho, Myung Haing | - |
dc.contributor.author | Choi, Wookhee | - |
dc.contributor.author | Kim, Sang-Wook | - |
dc.contributor.author | Kim, Younghun | - |
dc.contributor.author | Kim, Jae-Ho | - |
dc.date.accessioned | 2021-01-31T08:38:14Z | - |
dc.date.available | 2021-01-31T08:38:14Z | - |
dc.date.created | 2020-11-19 | - |
dc.date.created | 2020-11-19 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.citation | Archives of Toxicology, Vol.88 No.8, pp.1607-1618 | - |
dc.identifier.issn | 0340-5761 | - |
dc.identifier.other | 116767 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172306 | - |
dc.description.abstract | The unique properties of nanoparticles and biological systems are important factors affecting the biological response following nanoparticle exposure. Iron oxide nanoparticles are classified mainly as magnetite (M-FeNPs) and maghemite (NM-FeNPs). In our previous study, NM-FeNPs induced autophagic cell death in RAW264.7, a murine peritoneal macrophage cell line, which has excellent lysosomal activity. In this study, we compared the toxicity of M-FeNPs and NM-FeNPs in MH-S, a murine alveolar macrophage cell line, which has relatively low lysosomal activity. At 24 h post-exposure, M-FeNPs decreased cell viability and ATP production, and elevated the levels of reactive oxygen species, nitric oxide, and pro-inflammatory cytokines to a higher extent than NM-FeNPs. Damage of mitochondria and the endoplasmic reticulum and the down-regulation of mitochondrial function and transcription-related genes were also higher in cells exposed to M-FeNPs than in cells exposed to NM-FeNPs (50 mu g/ml). In addition, cells exposed to M-FeNPs (50 mu g/ml) showed an increase in the number of autophagosome-like vacuoles, whereas cells exposed to NM-FeNPs formed large vacuoles in the cytosol. However, an autophagy-related molecular response was not induced by exposure to either FeNPs, unlike the results seen in our previous study with RAW264.7 cells. We suggest that M-FeNPs induced higher toxicity compared to NM-FeNPs in MH-S cells, and lysosomal activity plays an important role in determining cell death pathway. | - |
dc.language | 영어 | - |
dc.publisher | Springer Verlag | - |
dc.title | Magnetite- and maghemite-induced different toxicity in murine alveolar macrophage cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1007/s00204-014-1210-1 | - |
dc.citation.journaltitle | Archives of Toxicology | - |
dc.identifier.wosid | 000339898700012 | - |
dc.identifier.scopusid | 2-s2.0-84904960926 | - |
dc.citation.endpage | 1618 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 1607 | - |
dc.citation.volume | 88 | - |
dc.identifier.sci | 000339898700012 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | OXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | FENTON REACTION | - |
dc.subject.keywordPlus | IRON TOXICITY | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | AUTOPHAGY | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | NECROPTOSIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordAuthor | Iron nanoparticles | - |
dc.subject.keywordAuthor | Magnetic | - |
dc.subject.keywordAuthor | Toxicity | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | Macrophage | - |
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