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Biological effect of recombinant human granulocytes colony- stimulating factor on X-ray irradiated mice with bone marrow transplantation
DC Field | Value | Language |
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dc.contributor.author | Kim, J.H. | - |
dc.contributor.author | Kim, S.H. | - |
dc.contributor.author | Kim, M.Y. | - |
dc.contributor.author | Shin, M.K. | - |
dc.contributor.author | Fang, M.Z. | - |
dc.contributor.author | Son, J.W. | - |
dc.contributor.author | Choi, J.H. | - |
dc.contributor.author | Bae, M.O. | - |
dc.contributor.author | Kim, J.S. | - |
dc.contributor.author | Lee, M.H. | - |
dc.contributor.author | Cho, M.H. | - |
dc.contributor.author | Kwon, S.C. | - |
dc.contributor.author | Jung, S.Y. | - |
dc.contributor.author | Bae, S.M. | - |
dc.contributor.author | Lee, G.S. | - |
dc.date.accessioned | 2021-01-31T08:38:46Z | - |
dc.date.available | 2021-01-31T08:38:46Z | - |
dc.date.created | 2018-04-12 | - |
dc.date.issued | 2001-11 | - |
dc.identifier.citation | Asia Pacific Journal of Pharmacology, Vol.15 No.4, pp.83-89 | - |
dc.identifier.issn | 0217-9687 | - |
dc.identifier.other | 32845 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172315 | - |
dc.description.abstract | Human granulocyte colony-stimulating factor (hG-CSF) is one of the hematopoietic factors that controls the differentiation of pluripotent stem cells in many types of blood cells during hematopoiesis. It also plays a key role in the stimulation of proliferation and differentiation of several types of blood cells including granulocytes and macrophages. This study examined the effects of recombinant hG-CSF (rhG-CSF) on the recovery of peripheral neutrophil number, DNA damage of peripheral blood and the survival rate of mice that received whole-body X-ray irradiation. rhG-CSFs were prepared by replacing the respective Met17 with Ser17, Ala17, and Gly17. [Ser17] G-CSF, [Ala17] G-CSF and [Gly17] G-CSF (10 μg/kg) each were administered subcutaneously to X-ray-irradiated mice for 21 days after the bone marrow transplantation. Treatment of rhG-CSF increased the neutrophil differentiation significantly. Peripheral neutrophil number and the ratio of myloid to erythoid in the bone marrow gradually recovered to the normal level from the 13th day. [Ser17] G-CSF-treated group was significantly different compared with the vehicle-treated group, and [Ala17] G-CSF and [Ser17] G-CSF-treated groups showed the highest levels on the 17th and 21st day, respectively. The mortality of [Ser17] G-CSF-treated group was the lowest compared to approximately 30% death rate of the vehicle-treated group. Moreover, on the average, micronucleus (MN) frequencies of all treated groups tended to decrease gradually from the 9th to the 25th day. MN frequencies of [Ser17] G-CSF and [Ala17] G-CSF-treated groups were significantly lower than those of the vehicle control group (p < 0.05) from the 13th day. This observation suggests that methionyl-free rhG-CSF might have a protective role in severely irradiated mice and application of [Ser17] G-CSF hastened the recovery of leukocytes and neutrophils in peripheral blood. | - |
dc.language | 영어 | - |
dc.publisher | Singapore University Press | - |
dc.title | Biological effect of recombinant human granulocytes colony- stimulating factor on X-ray irradiated mice with bone marrow transplantation | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.citation.journaltitle | Asia Pacific Journal of Pharmacology | - |
dc.identifier.scopusid | 2-s2.0-0035744297 | - |
dc.citation.endpage | 89 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 83 | - |
dc.citation.volume | 15 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, M.H. | - |
dc.contributor.affiliatedAuthor | Cho, M.H. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | Micronucleus | - |
dc.subject.keywordAuthor | Neutrophil | - |
dc.subject.keywordAuthor | Recombinant human granulocyte-colony stimulating factor (rhG-CSF) | - |
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